Evidence map›Paper›PMID 37267104›Full record

ArticleCell reports2023

Scanning mutagenesis of the voltage-gated sodium channel Na

Juan Lorenzo B Pablo, Savannah L Cornett, Lei A Wang, Sooyeon Jo, Tobias Brünger, Nikita Budnik, Mudra Hegde, Jean-Marc DeKeyser, Christopher H Thompson, John G Doench and 3 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Juan Lorenzo B PabloStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: jpablo@broadinstitute.org.
Savannah L CornettStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Lei A WangStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Sooyeon JoStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Tobias BrüngerCologne Center for Genomics, University of Cologne, 51149 Cologne, Germany; Genomic Medicine Institute, Lerner Research Institute, Neurological Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Nikita BudnikStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Mudra HegdeBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Jean-Marc DeKeyserDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Christopher H ThompsonDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
John G DoenchBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Dennis LalCologne Center for Genomics, University of Cologne, 51149 Cologne, Germany; Genomic Medicine Institute, Lerner Research Institute, Neurological Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Neurology, McGovern Medical School, UTHealth, Houston, TX 77030, USA.
Alfred L GeorgeDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Jen Q PanStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: jpan@broadinstitute.org.
Broad Institute · USNorthwestern University · USCleveland Clinic Lerner College of Medicine · USUniversity of Cologne · DE

Funding

Project 3 - Development and investigation of murine models of channelopathy-associated epilepsyU54NS108874 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KEARNEY, JENNIFER A · 2018 to 2022
$12.1M
Functional annotation of a comprehensive set of SCN2A variantsR21NS110355 · NINDS · BROAD INSTITUTE, INC. · PI GEORGE, ALFRED L., PAN, JEN QIAN · 2018 to 2019
$443k
NINDS NIH HHS R21 NS110355NINDS NIH HHS U54 NS108874
6 · The paper itself

Abstract

It is challenging to apply traditional mutational scanning to voltage-gated sodium channels (Na

Indexed as

Gene EditingNAV1.2 Voltage-Gated Sodium ChannelVoltage-Gated Sodium ChannelsMutagenesisMutationMutation, MissenseNAV1.2 Voltage-Gated Sodium ChannelVoltage-Gated Sodium Channelsbase editingchannelopathyCP: NeuroscienceCRISPRelectrophysiologyion channelsmutational screeningNaV1.2neurodevelopmental disordervariants to functionvoltage-gated sodium channel

Identifiers

PMID37267104
PMCPMC10592450
OpenAlexW4379056315

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.