ArticleCell reports2023
Liver and muscle circadian clocks cooperate to support glucose tolerance in mice.
Open access · goldAbstract read
In one paragraph
Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
7.7field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Pooled it
- Stable clocks, rewired rhythms: circadian remodeling in skeletal muscle during aging, cachexia, and type 2 diabetes.Life metabolism · 2026Review
- Rhythmic Metabolism in Osteosarcopenia: Emerging Evidence, a Chronometabolomic Framework for the Bone-Muscle Unit, and Research Priorities.Metabolites · 2026Review
- The dawn phenomenon in diabetes: pathophysiology from periphery to central nervous system and circadian rhythm-based therapeutic strategies.Acta diabetologica · 2026Review
- Timing the strain: skeletal muscle clock as regulator of physical activity.npj metabolic health and disease · 2026Review
- Co-expression network analysis reveals repression ofbioRxiv : the preprint server for biology · 2026Article
- Redox rhythms promote fitness by modulating ageing-dependent reprogramming.Nature metabolism · 2026Article
- The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mitochondrial Function.Journal of biological rhythms · 2026Article
- New insights into the skeletal muscle circadian clock in ruminants.Journal of animal science and biotechnology · 2026Review
- Sepsis induced coagulopathy (SIC): is it monolithic?Thrombosis journal · 2026Article
- BMAL1-GPX3 axis in the choroid plexus mitigates Aβ pathology in an amyloid mouse model.Journal of neuroinflammation · 2026Article
- Timing matters: circadian rhythm disruption in alcohol-associated peripheral organ pathophysiology.Function (Oxford, England) · 2026Review
- Review
- Effects of Chrono-Exercise and Chrono-Nutrition on Muscle Health: Understanding the Molecular Mechanisms Activated by Timed Exercise and Consumption of Proteins and Carbohydrates.Nutrition reviews · 2025Review
- Circadian disruption of feeding-fasting rhythm and its consequences for metabolic, immune, cancer, and cognitive processes.Biomedical journal · 2025Review
- Muscle peripheral circadian clock drives nocturnal protein degradation via raised Ror/Rev-erb balance and prevents premature sarcopenia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Frequent Shifts During Chronic Jet Lag Uncouple Liver Rhythms From the Light Cycle in Male Mice.Journal of biological rhythms · 2025Article
- Circadian clock communication during homeostasis and ageing.Nature reviews. Molecular cell biology · 2025Review
- Control of circadian muscle glucose metabolism through the BMAL1-HIF axis in obesity.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A Transcriptomic Dataset of Liver Tissues from Global and Liver-Specific Bmal1 Knockout Mice.Scientific data · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 10 institutions in 8 countries.
Jacob G SmithCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Department of Medical and Life Sciences (MELIS), Pompeu Fabra University (UPF), Parc de Recerca Biomèdica de Barcelona (PRBB), 08003 Barcelona, Spain. Electronic address: jacob.smith@upf.edu.
Kevin B KoronowskiCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, TX 78229, USA. Electronic address: koronowski@uthscsa.edu.
Thomas MortimerInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.
Tomoki SatoCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.
Carolina M GrecoCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Milan, Italy; IRCCS Humanitas Research Hospital, via Manzoni 56, 20089 Rozzano, Milan, Italy.
Paul PetrusCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Department of Medicine (H7), Karolinska Institutet, 141 86 Stockholm, Sweden.
Amandine VerlandeDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA 92697, USA.
Siwei ChenInstitute for Genomics and Bioinformatics, Department of Computer Science, University of California, Irvine, Irvine, CA 92697, USA.
Muntaha SamadInstitute for Genomics and Bioinformatics, Department of Computer Science, University of California, Irvine, Irvine, CA 92697, USA.
Ekaterina DeynekaInstitute for Genomics and Bioinformatics, Department of Computer Science, University of California, Irvine, Irvine, CA 92697, USA.
Lavina MathurDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA 92697, USA.
Ronnie BlazevCentre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Melbourne, VIC 3010, Australia.
Jeffrey MolendijkCentre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Melbourne, VIC 3010, Australia.
Arun KumarDepartment of Medical and Life Sciences (MELIS), Pompeu Fabra University (UPF), Parc de Recerca Biomèdica de Barcelona (PRBB), 08003 Barcelona, Spain.
Oleg DeryaginDepartment of Medical and Life Sciences (MELIS), Pompeu Fabra University (UPF), Parc de Recerca Biomèdica de Barcelona (PRBB), 08003 Barcelona, Spain.
Mireia Vaca-DempereDepartment of Medical and Life Sciences (MELIS), Pompeu Fabra University (UPF), Parc de Recerca Biomèdica de Barcelona (PRBB), 08003 Barcelona, Spain.
Valentina SicaDepartment of Medical and Life Sciences (MELIS), Pompeu Fabra University (UPF), Parc de Recerca Biomèdica de Barcelona (PRBB), 08003 Barcelona, Spain.
Peng LiuKing Abdullah University of Science and Technology, KAUST Environmental Epigenetics Research Program, Biological and Environmental Sciences and Engineering Division, Thuwal 23955, Saudi Arabia.
Valerio OrlandoKing Abdullah University of Science and Technology, KAUST Environmental Epigenetics Research Program, Biological and Environmental Sciences and Engineering Division, Thuwal 23955, Saudi Arabia.
Benjamin L ParkerCentre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Melbourne, VIC 3010, Australia.
Pierre BaldiInstitute for Genomics and Bioinformatics, Department of Computer Science, University of California, Irvine, Irvine, CA 92697, USA.
Patrick-Simon WelzInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain; Program in Cancer Research, Hospital del Mar Medical Research Institute (IMIM), Parc de Recerca Biomèdica de Barcelona (PRBB), 08003 Barcelona, Spain.
Cholsoon JangDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA 92697, USA.
Selma MasriDepartment of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA 92697, USA.
Salvador Aznar BenitahInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain; Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain. Electronic address: salvador.aznar-benitah@irbbarcelona.org.
Pura Muñoz-CánovesDepartment of Medical and Life Sciences (MELIS), Pompeu Fabra University (UPF), Parc de Recerca Biomèdica de Barcelona (PRBB), 08003 Barcelona, Spain; Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain; Altos Labs, Inc., San Diego Institute of Science, San Diego, CA 92121, USA. Electronic address: pmunozcanoves@altoslabs.com.
Paolo Sassone-CorsiCenter for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
University of California, Irvine · USInserm · FRUniversitat Pompeu Fabra · ESThe University of Melbourne · AUInstitució Catalana de Recerca i Estudis Avançats · ESKing Abdullah University of Science and Technology · SABarcelona Biomedical Research Park · ESHumanitas University · ITInstitute for Research in Biomedicine · ESUniversity of Shizuoka · JP
Funding
Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9MTRANSGENIC COREP30AG013319 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JAMES FLOYD NELSON · 1995 to 2026
$30.6MCARCINOGENESIST32CA009054 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI EDINGER, AIMEE L, FRUMAN, DAVID ALEXANDER · 1985 to 2025
$8.6MEpilepsy Research Training ProgramT32NS045540 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Tallie Z. Baram, Robert F Hunt · 2003 to 2026
$4.9MCircadian Clock and Myc-dependent Regulation of Cellular TransformationR01CA259370 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Selma Masri · 2022 to 2026
$3.0MCircadian Clock Disruption and Colorectal CancerR01CA244519 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Selma Masri · 2020 to 2026
$3.0MBioinformatics Tools for Circadian BiologyR01GM123558 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Pierre Baldi · 2017 to 2026
$2.4MElucidating dietary fructose and alcohol interactions during liver cancer developmentR01AA029124 · NIAAA · UNIVERSITY OF CALIFORNIA-IRVINE · PI JANG, CHOLSOON · 2021 to 2025
$2.0MFundamental Mechanisms of Higher-Order Circadian RhythmsR35GM150618 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Kevin B Koronowski · 2023 to 2026
$1.8MTumor Macroenvironment and the Circadian Metabolic ClockK22CA212045 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI MASRI, SELMA · 2018 to 2020
$607kHigh-Throughput DNA SequencerS10OD021718 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2016 to 2016
$600kPacBio RS Single Molecule, Real-Time (SMRT) DNA SequencerS10OD010794 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2012 to 2012
$600kNCI NIH HHS K22 CA212045NCI NIH HHS P30 CA062203NCI NIH HHS R01 CA244519NCI NIH HHS R01 CA259370NCI NIH HHS T32 CA009054NCRR NIH HHS S10 RR025496NIAAA NIH HHS R01 AA029124NIA NIH HHS P30 AG013319NIA NIH HHS R21 AG053592NIDDK NIH HHS F32 DK121425NIDDK NIH HHS R21 DK114652NIGMS NIH HHS R01 GM123558NIGMS NIH HHS R35 GM150618NIH HHS S10 OD010794NIH HHS S10 OD021718NINDS NIH HHS T32 NS045540
Abstract
Physiology is regulated by interconnected cell and tissue circadian clocks. Disruption of the rhythms generated by the concerted activity of these clocks is associated with metabolic disease. Here we tested the interactions between clocks in two critical components of organismal metabolism, liver and skeletal muscle, by rescuing clock function either in each organ separately or in both organs simultaneously in otherwise clock-less mice. Experiments showed that individual clocks are partially sufficient for tissue glucose metabolism, yet the connections between both tissue clocks coupled to daily feeding rhythms support systemic glucose tolerance. This synergy relies in part on local transcriptional control of the glucose machinery, feeding-responsive signals such as insulin, and metabolic cycles that connect the muscle and liver. We posit that spatiotemporal mechanisms of muscle and liver play an essential role in the maintenance of systemic glucose homeostasis and that disrupting this diurnal coordination can contribute to metabolic disease.
Indexed as
Circadian ClocksAnimalsCircadian RhythmGlucoseLiverMiceMuscle, SkeletalGlucoseautonomyBmal1circadian rhythmsCP: Metabolismendocrinologyglucoseinter-organ crosstalklivermetabolismmusclesystems biology
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.