ArticleEnvironmental health perspectives2023
Synthetic Phenolic Antioxidants and Their Metabolites in Follicular Fluid and Association with Diminished Ovarian Reserve: A Case-Control Study.
Article in Environmental health perspectives, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Assessment of ovarian dysfunction induced by environmental toxins: a systematic review.Frontiers in public health · 2025Pooled it
- Luteinizing hormone change trajectories in gonadotropin-releasing hormone antagonist protocols are associated with assisted reproductive outcomes: results from a retrospective cohort study.Journal of ovarian research · 2026Article
- HPA/HPG axes dysfunction: assessing the interrelations between diminished ovarian reserve and mental health.Journal of ovarian research · 2026Review
- Paeonol protects against cisplatin-induced premature ovarian failure via anti-inflammatory and antioxidant activities: an integrated approach of network pharmacology, molecular dynamics simulation, and experimental validation.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Clinical characteristics and associated risk factors for diminished ovarian reserve among Chinese women: a matched case-control study.Frontiers in endocrinology · 2026Article
- Article
- Phenol biomarker concentrations in human ovarian follicular fluid and the associations with in-vitro fertilization outcomes.International journal of hygiene and environmental health · 2025Article
- Alteration of Tear Metabolomics Profiling in Infants With Retinopathy of Prematurity.Investigative ophthalmology & visual science · 2025Article
- Distribution of Environmental Phenols into Follicular Fluid and Urine of Women Attending Infertility Clinic.Journal of xenobiotics · 2025Article
- Exploring dog saliva as a non-invasive alternative to blood sampling for chemical exposome studies: analysis of synthetic phenolic antioxidants and PFAS.Frontiers in veterinary science · 2025Article
- Association between novel per- and poly-fluoroalkyl substances and premature ovarian insufficiency: a case-control study.Human reproduction open · 2025Article
- The impact of chronic insomnia disorder on menstruation and ovarian reserve in childbearing-age women: A cross-sectional study.Clinical and experimental reproductive medicine · 2024Article
- Thermal decomposition characteristics of BHT and its peroxide (BHTOOH).BMC chemistry · 2024Article
- Metabolomic Analysis Reveals Association between Decreased Ovarian Reserve and In Vitro Fertilization Outcomes.Metabolites · 2024Article
- Reproductive toxicology of environmental endocrine-disrupting chemicals in women: a cohort study protocol.Frontiers in cell and developmental biology · 2024Article
- Invited Perspective: Measuring Biomarkers of Exposure in Target Organs-What Is Needed to Move Forward?Environmental health perspectives · 2023Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiminished/decreased ovarian reserve (DOR) is a disorder of ovarian function, which severely affects women's reproductive health. Accumulating evidence has found that adverse environmental factors can affect ovarian function. However, whether synthetic phenolic antioxidants (SPAs) exposure is associated with DOR is still unknown.
objectivesWe explored whether concentrations of SPAs and their metabolites are associated with DOR.
methodsA case-control study was conducted from January 2019 to January 2020 in China. One hundred eighty-one women 20-44 years of age, with (case group,
resultsThe measured frequencies of BHA, TBHQ, BHT, BHT-OH, BHT-CHO, BHT-COOH, BHT-Q, and BHT-quinol in follicular fluid were 1.7%, 2.2%, 40.3%, 46.4%, 57.5%, 100%, 64.6%, and 49.2%, respectively. The concentrations of BHT-CHO (
conclusionIn this study, we report the measured frequency and concentrations of BHA, TBHQ, BHT, and their metabolites in follicular fluid. Moreover, we found the concentrations of BHT metabolites, especially BHT-CHO, BHT-COOH, and BHT-Q, are positively associated with the increased risk of DOR. https://doi.org/10.1289/EHP11309.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.