Evidence map›Paper›PMID 37266986›Full record

ArticleJournal of medical Internet research2023

A Video-Observed Treatment Strategy to Improve Adherence to Treatment Among Persons Who Inject Drugs Infected With Hepatitis C Virus: Qualitative Study of Stakeholder Perceptions and Experiences.

Alison Karasz, Krupa Merchant, Julia Arnsten, Judith Feinberg, Arthur Y Kim, Paula J Lum, Melissa Diane McKee, Shruti H Mehta, Paul Meissner, Brianna L Norton and 8 more

Abstract read
In one paragraph

Article in Journal of medical Internet research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Alison KaraszUniversity of Massachusetts Chan Medical School, Worcester, MA, United States.ORCID 0000-0003-3038-2751
Krupa MerchantNorthwestern Memorial Hospital, Chicago, IL, United States.ORCID 0009-0008-0811-7074
Julia ArnstenMontefiore Medical Center, Bronx, NY, United States.ORCID 0000-0002-7741-1567
Judith FeinbergWest Virginia University School of Medicine, Morgantown, WV, United States.ORCID 0000-0003-4206-7214
Arthur Y KimHarvard Medical School, Boston, MA, United States.ORCID 0000-0003-4712-2657
Paula J LumUniversity of California, San Francisco, San Francisco, CA, United States.ORCID 0000-0002-0833-8642
Melissa Diane McKeeUniversity of Massachusetts Chan Medical School, Worcester, MA, United States.ORCID 0000-0002-1228-718X
Shruti H MehtaJohns Hopkins University, Baltimore, MD, United States.ORCID 0000-0002-2523-0959
Paul MeissnerMontefiore Medical Center, Bronx, NY, United States.ORCID 0000-0003-3424-2481
Brianna L NortonMontefiore Medical Center, Bronx, NY, United States.ORCID 0000-0002-8287-2245
Kimberly PageUniversity of New Mexico, Albuquerque, NM, United States.ORCID 0000-0002-7120-1673
Irene Pericot-ValverdeClemson University, Greenville, SC, United States.ORCID 0000-0001-5814-0397
Reena SinghMontefiore Medical Center, Bronx, NY, United States.ORCID 0000-0002-1636-1375
Ellen SteinUniversity of California, San Francisco, San Francisco, CA, United States.ORCID 0000-0003-3864-4891
Lynn E TaylorUniversity of Rhode Island, Providence, RI, United States.ORCID 0000-0002-0472-8125
Judith I TsuiUniversity of Washington School of Medicine, Seattle, WA, United States.ORCID 0000-0003-0877-5399
Katherine WagnerUniversity of New Mexico, Albuquerque, NM, United States.ORCID 0009-0004-4855-9513
Alain LitwinPrisma Health/Clemson University, Greenville, SC, United States.ORCID 0000-0002-6717-0288

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDirect-acting antiviral medications have the potential to eliminate the hepatitis C virus (HCV) epidemic among people who inject drugs; yet, suboptimal adherence remains a barrier. Directly observed treatment (DOT), an effective strategy for optimizing adherence, has been frequently implemented in opioid treatment programs but less commonly in community health settings due to the heavy burden of daily visits. An alternative is video-observed therapy (VOT), which uses mobile health technology to monitor adherence. VOT has not been widely studied among people who inject drugs with HCV.

objectiveThis qualitative study, part of a larger implementation evaluation, investigates stakeholder perceptions and experiences with VOT in Project HERO (Hepatitis C Real Outcomes), a multisite pragmatic trial testing treatment delivery models for people who inject drugs with HCV. Our goal was to understand the potential barriers and facilitators to the implementation of the VOT technology.

methodsQualitative interviews were conducted with 27 Project HERO study staff and 7 patients. Interviews focused on perceptions and experiences with the VOT app and barriers and facilitators to implementation. Team meeting minutes over the first 2 years of the project were transcribed. A coding system was developed and applied to the data. We summarized thematic data and compared participant perceptions to generate a close understanding of the data.

resultsFrequent barriers to VOT included mechanical failure, stolen or lost phones, and a steep learning curve for participants and study staff. In sites with older and less technically skilled participants, staff found it difficult to implement the VOT app. Research staff found that the routine monitoring of app use led to closer engagement with participants. This was both a benefit and a potential threat to the validity of this pragmatic trial. Patient participants reported mixed experiences.

conclusionsVOT may be a useful alternative to DOT for some patients, but it may not be feasible for all. Significant staff involvement may be required.

Indexed as

Drug UsersHepatitis CHepatitis C, ChronicSubstance Abuse, IntravenousAntiviral AgentsHepacivirusHumansPharmaceutical PreparationsAntiviral AgentsPharmaceutical Preparationsadherenceadherence behaviorantiviralbehavior interventiondigital healthdirectly observed treatmentHCVhepatitis C virusmHealthmobile healthopioid treatmentperceptionpersons who inject drugstelemedicinetherapytreatmentvideo-observed therapy

Identifiers

PMID37266986
PMCPMC10276322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.