Evidence map›Paper›PMID 37266757›Full record

ArticleAMB Express2023

Effects of Pu-erh and Dian Hong tea polyphenols on the gut-liver axis in mice.

Ning Wang, Chaohua Lan, Muhammad Aamer Mehmood, Manli He, Xiongjun Xiao, Linman Li, Dalong Liao, Kewei Xu, Shan Mo, Puyu Zhang and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AMB Express, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Ning Wang *College of Bioengineering, Sichuan University of Science and Engineering, Zigong, 643000, China.
Chaohua Lan *College of Bioengineering, Sichuan University of Science and Engineering, Zigong, 643000, China.
Muhammad Aamer MehmoodCollege of Bioengineering, Sichuan University of Science and Engineering, Zigong, 643000, China.
Manli HeLaboratory Animal Center, Southwest Medical University, Luzhou, Sichuan, China.
Xiongjun XiaoCollege of Bioengineering, Sichuan University of Science and Engineering, Zigong, 643000, China.
Linman LiCollege of Bioengineering, Sichuan University of Science and Engineering, Zigong, 643000, China.
Dalong LiaoCollege of Bioengineering, Sichuan University of Science and Engineering, Zigong, 643000, China.
Kewei XuCollege of Bioengineering, Sichuan University of Science and Engineering, Zigong, 643000, China.
Shan MoCollege of Bioengineering, Sichuan University of Science and Engineering, Zigong, 643000, China.
Puyu ZhangCollege of Bioengineering, Sichuan University of Science and Engineering, Zigong, 643000, China.
Xiaoli ZhouCollege of Bioengineering, Sichuan University of Science and Engineering, Zigong, 643000, China.
Baoxiang GuCollege of Bioengineering, Sichuan University of Science and Engineering, Zigong, 643000, China.
Hui ZhuCollege of Bioengineering, Sichuan University of Science and Engineering, Zigong, 643000, China. zhuhuiwn@outlook.com.ORCID http://orcid.org/0000-0002-8967-3177
Tao WuSchool of Food and Biological Engineering, Xihua University, Chengdu, 610039, China. wutaobox@gmail.com.
Sichuan University of Science and Engineering · CNGovernment College University, Faisalabad · PKHunan Agricultural University · CNSouthwest Medical University · CNXihua University · CN

Funding

the Academician (Expert) Workstation Project of Sichuan University of Science &Engineering grant no. 2018YSCZZ01the Innovation and Entrepreneurship Program for College Students grant nos. S202210622023, cx2021140the Science and Technology Department of Sichuan Province grant no. 2020YFH0130the Talent Introduction Project of Sichuan University of Science & Engineering grant no. 2019RC29
6 · The paper itself

Abstract

Tea polyphenols (TP) are the most biologically active components in tea, with antioxidant, antiobesity, and antitumor properties, as well as the ability to modulate the composition and function of intestinal microbiota. This experimental study evaluated the chemical constituents of polyphenols in Pu-erh (PTP) and Dian Hong tea (DHTP). It also investigated the co-regulatory effects of PTP and DHTP on intestinal flora and liver tissues in mice using 16 S rRNA gene and transcriptome sequencing. The results revealed that DHT had higher concentrations of EGC (epigallocatechin), C (catechin), EC (epicatechin), and EGCG (epigallocatechin gallate). In contrast, PT had higher concentrations of GA (gallic acid), ECG (epicatechin-3-gallate), TF (theaflavin), and TB (theabrownin). PTP and DHTP consumption significantly reduced the rates of weight gain in mice. Microbial community diversity was significantly higher in PTP and DHTP-treated mice than in the control group. Notably, beneficial microbes such as Lactobacillus increased significantly in PTP-treated mice, whereas Lachnospiraceae increased significantly in DHTP-treated mice. Both PTP and DHTP improved the activity of the antioxidant enzymes (SOD) and total antioxidant capacity (T-AOC) in the liver. The transcriptome analysis revealed that the beneficial effects of PTP and DHTP were due to changes in various metabolic pathways, the majority of which were related to antioxidant and lipid metabolism. This study discovered that PTP and DHTP had beneficial effects in mice via the gut-liver axis.

Indexed as

AntioxidativeIntestinal microbiotaLipid metabolismTea polyphenols

Identifiers

PMID37266757
PMCPMC10236074
OpenAlexW4379095371

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.