Evidence map›Paper›PMID 37266730›Full record

ArticleCell biology and toxicology2023

GPR116 promotes ferroptosis in sepsis-induced liver injury by suppressing system Xc

Ying Wang, Ting Wang, Qian Xiang, Na Li, Jun Wang, Jiahao Liu, Yan Zhang, Tao Yang, Jinjun Bian

Abstract read
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In one paragraph

Article in Cell biology and toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Adhesion G protein-coupled receptors.Pharmacological reviews · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ying Wang *Department of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Ting Wang *Department of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Qian Xiang *Department of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Na LiDepartment of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Jun WangDepartment of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Jiahao LiuDepartment of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Yan ZhangDepartment of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Tao YangDepartment of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Jinjun BianDepartment of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. jinjunbian@smmu.edu.cn.

Funding

National Natural Science Foundation of China 82072220National Natural Science Foundation of China 82272205
6 · The paper itself

Abstract

The disease sepsis is caused by an infection that damages organs. Liver injury, with ferroptosis playing a key role, is an early sign of sepsis. G protein-coupled receptor 116 (GPR116) is essential in the maintenance of functional homeostasis in various systems of the body and has been proven to play a protective role in septic lung injury. However, it's role in septic liver injury remains unclear. In this study, we found that hepatic ferroptosis during sepsis was accompanied by GPR116 upregulation. Hepatocyte-specific GPR116 gene deletion can prevent hepatic ferroptosis, thereby alleviating sepsis-induced liver dysfunction and improving mouse survival, which was verified in vivo. Mechanistically, GPR116 aggravated mitochondrial damage and lipid peroxidation in hepatocytes by inhibiting system Xc

Indexed as

Chemical and Drug Induced Liver Injury, ChronicFerroptosisSepsisAnimalsHepatocytesMiceFerroptosisGPR116Lipid peroxidationLiver dysfunctionSepsis

Identifiers

PMID37266730

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.