Evidence map›Paper›PMID 37266586›Full record

Trial reportEuropean journal of nutrition2023

Effect of 1-year daily protein supplementation and physical exercise on muscle protein synthesis rate and muscle metabolome in healthy older Danes: a randomized controlled trial.

Jacob Bülow, Bekzod Khakimov, Søren Reitelseder, Rasmus Bechshøft, Mikkel Jensen, Gerrit van Hall, Søren Balling Engelsen, Lars Holm

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02115698 (Counteracting Age-related Loss of Skeletal Muscle Mass), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02115698 nacompletednot on this map

Counteracting Age-related Loss of Skeletal Muscle Mass

TypeinterventionalSponsorBispebjerg HospitalRan2014 to 2019Enrolled66ConditionsSarcopenia, Muscle LossArmsHeavy Resistance Training, Light Intensity Training, Protein Whey, Protein Collagen, Carbohydrate
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Jacob BülowDepartment of Orthopedic Surgery M, Institute of Sports Medicine Copenhagen M81, Bispebjerg Hospital, Building 8, Level 1, Nielsine Nielsens Vej 11, 2400, Copenhagen NV, Denmark. jacob.buelow.02@regionh.dk.ORCID http://orcid.org/0000-0003-2389-2657
Bekzod KhakimovDepartment of Food Sciences, University of Copenhagen, Copenhagen, Denmark.
Søren ReitelsederDepartment of Orthopedic Surgery M, Institute of Sports Medicine Copenhagen M81, Bispebjerg Hospital, Building 8, Level 1, Nielsine Nielsens Vej 11, 2400, Copenhagen NV, Denmark.
Rasmus BechshøftDepartment of Orthopedic Surgery M, Institute of Sports Medicine Copenhagen M81, Bispebjerg Hospital, Building 8, Level 1, Nielsine Nielsens Vej 11, 2400, Copenhagen NV, Denmark.
Mikkel JensenDepartment of Orthopedic Surgery M, Institute of Sports Medicine Copenhagen M81, Bispebjerg Hospital, Building 8, Level 1, Nielsine Nielsens Vej 11, 2400, Copenhagen NV, Denmark.
Gerrit van HallDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Søren Balling EngelsenDepartment of Food Sciences, University of Copenhagen, Copenhagen, Denmark.
Lars HolmDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
University of Copenhagen · DKBispebjerg Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe skeletal muscle mass decreases with age and the responsiveness of aging muscles' protein synthesis rate (MPS) to protein intake seems to deteriorate.

objectiveThis study investigated the impact of 12 months of protein supplementation with or without physical exercise training on the basal and postprandial MPS and the skeletal muscle metabolome of healthy older Danes (> 65 years, 29 females/37 males).

methodsSubjects were randomized to follow one of five intervention groups: (1) carbohydrate, (2) collagen protein, (3) whey protein, (4) home-based light resistance training with whey protein, and (5) center-based heavy-load resistance training with whey protein. Before and after the intervention, a tracer infusion trial was conducted to measure basal and postprandial MPS in response to intake of a cocktail consisting of 20 g whey hydrolysate + 10 g glucose. In addition, the skeletal muscle metabolome was measured using gas chromatography-mass spectrometry (GC-MS) at basal state and 4 h after the intake of the cocktail.

resultsOne year of daily protein or carbohydrate supplementation did not alter the basal and protein-stimulated postprandial muscle protein synthesis rate or the muscle metabolome of healthy older Danes. Basal MPS (%/h) at baseline for all subjects were 0.0034 ± 0,011 (mean ± SD). In contrast to previous studies, no difference was observed in basal MPS between males and females (p = 0.75). With the developed untargeted GC-MS methodology, it was possible to detect and tentatively annotate > 70 metabolites from the human skeletal muscle samples.

conclusionOne year of protein supplementation in comparison to an isocaloric-control supplement seems to affect neither the MPS at basal or postprandial state nor the skeletal muscle metabolome. CLINICAL TRIAL REGISTRY: Number: NCT02115698, clinicaltrials.gov/ct2/show/NCT02115698.

Indexed as

Muscle ProteinsResistance TrainingAgedCarbohydratesDietary SupplementsDouble-Blind MethodExerciseFemaleHumansMaleMetabolomeMuscle, SkeletalScandinavians and Nordic PeopleWhey ProteinsCarbohydratesMuscle ProteinsWhey ProteinsAgingHealthy agingHealthy older adultsMuscle metabolomeProtein supplementationProtein synthesisSarcopeniaTraining

Identifiers

PMID37266586
PMCPMC10421766
OpenAlexW4379093737

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.