ReviewFrontiers in immunology2023
Cellular activation pathways and interaction networks in vascularized composite allotransplantation.
Review in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- A systematic review of treatment strategies to combat acute and chronic rejection episodes in vascularized composite allotransplantation.Frontiers in immunology · 2026Pooled it
- Bio-boosting transplants: a systematic review on biopolymers in vascular composite allotransplantation.Frontiers in immunology · 2025Pooled it
- The role of C4d and donor specific antibodies in face and hand transplantation-a systematic review.Frontiers in transplantation · 2024Pooled it
- Vascularized composite xenotransplantation: Where we have been and where we could go?Cell transplantationPooled it
- Review
- Diagnostic modalities in vascularized composite allotransplantation: from histopathology to multimodal strategies.Frontiers in immunology · 2026Review
- Chronic Rejection in Facial Vascularized Composite Allotransplantation (fVCA).Results and problems in cell differentiation · 2026Review
- CAR-T cell therapy and reconstructive oncologic surgery in peripheral solid tumors-A narrative review.Cell reports. Medicine · 2025Review
- Development of Thymic Organoids Heterotopically to Educate and Induce T Lymphocytes.Immunity, inflammation and disease · 2025Article
- Unraveling the Roles of Macrophages in Vascularized Composite Allotransplantation.Biomedicines · 2025Review
- Ten-year follow-up after face transplantation-A single-center retrospective cohort study.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025Article
- Urinary bladder transplantation in humans - current status and future perspectives.Nature reviews. Urology · 2025Review
- A comparative analysis of lesional skin, sentinel flap, and mucosal biopsies in assessing acute face transplant rejection.Frontiers in immunology · 2025Article
- Donor adipose-derived stromal cells are vasoprotectant but unable to revert acute rejection in rodent vascularized composite allotransplants.Frontiers in immunology · 2025Article
- Differentiation of acute versus chronic skin rejection in a rodent model of vascularized composite allotransplantation.Frontiers in immunology · 2025Article
- Immunosuppressive and antiinfectious regimens in vascular composite allograft recipients-a systematic review.Frontiers in transplantation · 2025Review
- Vascularised Composite Allotransplantation - A guide to optimal dissemination of scientific outputs.Journal of hand and microsurgery · 2025Article
- Thermal Rejection Assessment: New Strategies for Early Detection.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Reconstructive Paradigms: A Problem-Solving Approach in Complex Tissue Defects.Journal of clinical medicine · 2024Review
- Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions.Frontiers in immunology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
Abstract
Vascularized composite allotransplantation (VCA) is an evolving field of reconstructive surgery that has revolutionized the treatment of patients with devastating injuries, including those with limb losses or facial disfigurement. The transplanted units are typically comprised of different tissue types, including skin, mucosa, blood and lymphatic vasculature, muscle, and bone. It is widely accepted that the antigenicity of some VCA components, such as skin, is particularly potent in eliciting a strong recipient rejection response following transplantation. The fine line between tolerance and rejection of the graft is orchestrated by different cell types, including both donor and recipient-derived lymphocytes, macrophages, and other immune and donor-derived tissue cells (e.g., endothelium). Here, we delineate the role of different cell and tissue types during VCA rejection. Rejection of VCA grafts and the necessity of life-long multidrug immunosuppression remains one of the major challenges in this field. This review sheds light on recent developments in decoding the cellular signature of graft rejection in VCA and how these may, ultimately, influence the clinical management of VCA patients by way of novel therapies that target specific cellular processes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.