Evidence map›Paper›PMID 37266390›Full record

ArticleIEEE transactions on affective computing

Exploring Complexity of Facial Dynamics in Autism Spectrum Disorder.

Pradeep Raj Krishnappa Babu, J Matias Di Martino, Zhuoqing Chang, Sam Perochon, Kimberly L H Carpenter, Scott Compton, Steven Espinosa, Geraldine Dawson, Guillermo Sapiro

Open access · greenAbstract read
In one paragraph

Article in IEEE transactions on affective computing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Autism Digital Phenotyping in Preschool- and School-Age Children.Autism research : official journal of the International Society for Autism Research · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Complexity analysis of head movements in autistic toddlers.Journal of child psychology and psychiatry, and allied disciplines · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Pradeep Raj Krishnappa BabuDepartment of Electrical and Computer Engineering, Duke University, Durham, NC, USA.
J Matias Di MartinoDepartment of Electrical and Computer Engineering, Duke University, Durham, NC, USA.
Zhuoqing ChangDepartment of Electrical and Computer Engineering, Duke University, Durham, NC, USA.
Sam PerochonDepartment of Electrical and Computer Engineering, Duke University, Durham, NC, USA.
Kimberly L H CarpenterDuke Center for Autism and Brain Development, Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Scott ComptonDuke Center for Autism and Brain Development, Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Steven EspinosaOffice of Information Technology, Duke University, Durham, NC, USA.
Geraldine DawsonDuke Center for Autism and Brain Development, Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC. USA.
Guillermo SapiroDepartment of Electrical and Computer Engineering, Biomedical Engineering, Mathematics, and Computer Sciences, Duke University, Durham, NC, USA.
Duke University · US

Funding

Recruitment and Assessment CoreP50HD093074 · NICHD · DUKE UNIVERSITY · PI SCOTT N COMPTON · 2017 to 2026
$27.6M
ZOOMED FUNCT IMAGING IN HUMAN BRAIN AT 7T W/ SIMULT HIGH SPATIAL &TEMPORAL RESP41RR008079 · NCRR · UNIVERSITY OF MINNESOTA TWIN CITIES · PI VAUGHAN, JOHN T · 1993 to 2011
$16.3M
Novel Approaches to Infant Screening for ASD in Pediatric Primary CareR01MH121329 · NIMH · DUKE UNIVERSITY · PI DAWSON, GERALDINE · 2019 to 2023
$3.9M
Scalable Computational Platform For Active Closed-Loop Behavioral Coding in Autism Spectrum DisorderR01MH120093 · NIMH · DUKE UNIVERSITY · PI DAWSON, GERALDINE, SAPIRO, GUILLERMO R · 2019 to 2022
$1.6M
SCH: INT: Computational Tools for Avoidaint/Restrictive Food Intake Disorder R01MH122370 · NIMH · DUKE UNIVERSITY · PI SAPIRO, GUILLERMO R, ZUCKER, NANCY L · 2019 to 2021
$860k
NCRR NIH HHS P41 RR008079NICHD NIH HHS P50 HD093074NIMH NIH HHS R01 MH120093NIMH NIH HHS R01 MH121329NIMH NIH HHS R01 MH122370
6 · The paper itself

Abstract

Atypical facial expression is one of the early symptoms of autism spectrum disorder (ASD) characterized by reduced regularity and lack of coordination of facial movements. Automatic quantification of these behaviors can offer novel biomarkers for screening, diagnosis, and treatment monitoring of ASD. In this work, 40 toddlers with ASD and 396 typically developing toddlers were shown developmentally-appropriate and engaging movies presented on a smart tablet during a well-child pediatric visit. The movies consisted of social and non-social dynamic scenes designed to evoke certain behavioral and affective responses. The front-facing camera of the tablet was used to capture the toddlers' face. Facial landmarks' dynamics were then automatically computed using computer vision algorithms. Subsequently, the complexity of the landmarks' dynamics was estimated for the eyebrows and mouth regions using multiscale entropy. Compared to typically developing toddlers, toddlers with ASD showed higher complexity (i.e., less predictability) in these landmarks' dynamics. This complexity in facial dynamics contained novel information not captured by traditional facial affect analyses. These results suggest that computer vision analysis of facial landmark movements is a promising approach for detecting and quantifying early behavioral symptoms associated with ASD.

Indexed as

Affective stateAutism spectrum disorderComplexityFacial dynamicsMultiscale entropySample entropy

Identifiers

PMID37266390
PMCPMC10231874
OpenAlexW3199687520

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.