Evidence map›Paper›PMID 37266339›Full record

ArticleContemporary oncology (Poznan, Poland)2023

Association between single nucleotide polymorphisms in DNA repair genes and the efficacy of radiotherapy in nasopharyngeal carcinoma patients.

Rajaa Benzeid, Amin Gihbid, Nezha Tawfik, Nadia Benchakroun, Karima Bendahhou, Abdellatif Benider, Amal Guensi, Naima El Benna, Abdelkarim Filali Maltouf, Mohammed El Mzibri and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary oncology (Poznan, Poland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Rajaa BenzeidBiology and Medical Research Unit, National Center of Energy, Sciences and Nuclear Techniques, Rabat, Morocco.
Amin GihbidLaboratory of Viral Oncology, Institut Pasteur du Maroc, Casablanca, Morocco.
Nezha TawfikMohammed VI Centre for Cancer Treatment, Ibn Rochd University Hospital, Casablanca, Morocco.
Nadia BenchakrounMohammed VI Centre for Cancer Treatment, Ibn Rochd University Hospital, Casablanca, Morocco.
Karima BendahhouMohammed VI Centre for Cancer Treatment, Ibn Rochd University Hospital, Casablanca, Morocco.
Abdellatif BeniderMohammed VI Centre for Cancer Treatment, Ibn Rochd University Hospital, Casablanca, Morocco.
Amal GuensiMohammed VI Centre for Cancer Treatment, Ibn Rochd University Hospital, Casablanca, Morocco.
Naima El BennaMohammed VI Centre for Cancer Treatment, Ibn Rochd University Hospital, Casablanca, Morocco.
Abdelkarim Filali MaltoufLaboratory of Microbiology and Molecular Biology, Faculty of Sciences, Rabat, Morocco.
Mohammed El MzibriBiology and Medical Research Unit, National Center of Energy, Sciences and Nuclear Techniques, Rabat, Morocco.
Mohammed AttalebBiology and Medical Research Unit, National Center of Energy, Sciences and Nuclear Techniques, Rabat, Morocco.
Meriem KhyattiLaboratory of Viral Oncology, Institut Pasteur du Maroc, Casablanca, Morocco.
Imane ChaouiBiology and Medical Research Unit, National Center of Energy, Sciences and Nuclear Techniques, Rabat, Morocco.
Centre Hospitalier Universitaire Ibn Rochd · MANational Centre for Nuclear Energy, Science and Technology · MAInstitut Pasteur du Maroc · MA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Single nucleotide polymorphisms (SNPs) in DNA repair genes are mainly correlated with the response to radiotherapy in nasopharyngeal cancer (NPC). In NPC patients, previous research has studied the association between X-ray repair cross-complementing group 1 and 3 (XRCC1 and XRCC3) polymorphisms and radio-therapeutic response. The objective of our study was to test the association between XRCC1 Arg399Gln and XRCC3 Thr241Met polymorphisms and the response to radiotherapy in the NPC Moroccan population. Material and methods: A total of 100 patients with NPC were genotyped for polymorphisms in XRCC1 and XRCC3 genes. Results: The results revealed that the genotypes and alleles of both SNPs did not show any significant association with clinical stages (for XRCC1 Arg399Gln: Conclusions: The present study suggests that XRCC1 Arg399Gln polymorphism does not have any impact on the radio-therapeutic response in Moroccan NPC patients whereas XRCC3 Thr241Met polymorphism may act as a prognostic indicator for NPC patients treated with radiotherapy. However, studies with a larger sample are needed to confirm our results.

Indexed as

NPCpolymorphismsradioresistanceradiotherapySNPs

Identifiers

PMID37266339
PMCPMC10230242
OpenAlexW4377289289

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.