Evidence map›Paper›PMID 37265865›Full record

ArticleEuropean heart journal. Digital health2023

Development and validation of explainable machine learning models for risk of mortality in transcatheter aortic valve implantation: TAVI risk machine scores.

Andreas Leha, Cynthia Huber, Tim Friede, Timm Bauer, Andreas Beckmann, Raffi Bekeredjian, Sabine Bleiziffer, Eva Herrmann, Helge Möllmann, Thomas Walther and 10 more

Open access · goldAbstract read
In one paragraph

Article in European heart journal. Digital health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 4 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 4 syntheses or guidelines pooled it, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 11 institutions in 2 countries.

Andreas LehaDepartment of Medical Statistics, University Medical Center Göttingen, Humboldtallee 32, 37073 Göttingen, Germany.ORCID https://orcid.org/0000-0002-8072-1988
Cynthia HuberDepartment of Medical Statistics, University Medical Center Göttingen, Humboldtallee 32, 37073 Göttingen, Germany.ORCID https://orcid.org/0000-0003-2035-3682
Tim FriedeDepartment of Medical Statistics, University Medical Center Göttingen, Humboldtallee 32, 37073 Göttingen, Germany.ORCID https://orcid.org/0000-0001-5347-7441
Timm BauerDepartment of Cardiology, Sana Klinikum Offenbach, Starkenburgring 66, 63069 Offenbach am Main, Germany.
Andreas BeckmannGerman Society for Thoracic and Cardiovascular Surgery, Langenbeck-Virchow-Haus, Luisenstraße 58/59, 10117 Berlin, Germany.
Raffi BekeredjianDepartment of Cardiology, Robert-Bosch-Krankenhaus, Auerbachstraße 110, 70376 Stuttgart, Germany.ORCID https://orcid.org/0000-0002-7666-6859
Sabine BleizifferClinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center Northrhine-Westphalia, Georgstr 11, 32545 Bad Oeynhausen, Germany.ORCID https://orcid.org/0000-0001-9669-7372
Eva HerrmannGoethe University Frankfurt, Department of Medicine, Institute of Biostatistics and Mathematical Modelling, Theodor-Stern-Kai 7, 60590 Frankfurt Main, Germany.ORCID https://orcid.org/0000-0002-0662-6675
Helge MöllmannDepartment of Cardiology, St.-Johannes-Hospital Dortmund, Johannesstrasse 9-17, 44137 Dortmund, Germany.
Thomas WaltherDepartment of Cardiothoracic Surgery, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.ORCID https://orcid.org/0000-0002-2892-8949
Friedhelm BeyersdorfMedical Faculty of the Albert-Ludwigs-University Freiburg, University Hospital Freiburg, Hugstetterstr. 55, 79106 Freiburg, Germany.ORCID https://orcid.org/0000-0003-2975-2751
Christian HammDepartment of Cardiology and Angiology, University Hospital Gießen, Klinikstr. 33, 35392 Gießen, Germany.
Arnaud KünziCTU Bern, University of Bern, Mittelstrasse 43, 3012 Bern, Switzerland.ORCID https://orcid.org/0000-0003-3115-9156
Stephan WindeckerDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.ORCID https://orcid.org/0000-0002-4488-1335
Stefan StorteckyDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.ORCID https://orcid.org/0000-0002-5076-0177
Ingo KutschkaClinic for Cardiothoracic and Vascular Surgery/Heart Center, University Medical Center Göttingen, Robert-Koch Str. 40, 37075 Göttingen, Germany.ORCID https://orcid.org/0000-0002-7358-3513
Gerd HasenfußDZHK (German Center for Cardiovascular Research), Partner Site Göttingen, Robert-Koch str. 40, 37075 Göttingen, Germany.ORCID https://orcid.org/0000-0002-5942-361X
Stephan EnsmingerDepartment of Cardiac and Thoracic Vascular Surgery, University Heart Center Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.ORCID https://orcid.org/0000-0002-9508-3261
Christian FrerkerDepartment of Cardiology, University Heart Center Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.
Tim SeidlerDZHK (German Center for Cardiovascular Research), Partner Site Göttingen, Robert-Koch str. 40, 37075 Göttingen, Germany.ORCID https://orcid.org/0000-0002-6158-5087
Universitätsmedizin Göttingen · DEUniversity of Bern · CHGerman Centre for Cardiovascular Research · DEGoethe University Frankfurt · DEGerman Society for Thoracic and Cardiovascular Surgery · DEHeart and Diabetes Center North Rhine-Westphalia · DERobert Bosch Hospital · DESana Klinikum Offenbach · DESt.-Johannes-Hospital Dortmund · DEUniversitätsklinikum Gießen und Marburg · DEUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Identification of high-risk patients and individualized decision support based on objective criteria for rapid discharge after transcatheter aortic valve implantation (TAVI) are key requirements in the context of contemporary TAVI treatment. This study aimed to predict 30-day mortality following TAVI based on machine learning (ML) using data from the German Aortic Valve Registry. Methods and results: Mortality risk was determined using a random forest ML model that was condensed in the newly developed TAVI Risk Machine (TRIM) scores, designed to represent clinically meaningful risk modelling before (TRIMpre) and in particular after (TRIMpost) TAVI. Algorithm was trained and cross-validated on data of 22 283 patients (729 died within 30 days post-TAVI) and generalisation was examined on data of 5864 patients (146 died). TRIMpost demonstrated significantly better performance than traditional scores [ Conclusion: TRIM scores demonstrate good performance for risk estimation before and after TAVI. Together with clinical judgement, they may support standardised and objective decision-making before and after TAVI.

Indexed as

decision supportmachine learningrandom forestrisk scoreTAVI

Identifiers

PMID37265865
PMCPMC10232286
OpenAlexW4327739783

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.