Evidence map›Paper›PMID 37265855›Full record

ArticleJournal of the American College of Clinical Pharmacy : JACCP2021

A cluster randomized trial to evaluate a centralized remote clinical pharmacy service in large, health system primary care clinics.

Korey Kennelty, Christopher S Coffey, Gail Ardery, Liz Uribe, Jon Yankey, Dixie Ecklund, Paul A James, Mark W Vander Weg, Elizabeth A Chrischilles, Alan J Christensen and 3 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Journal of the American College of Clinical Pharmacy : JACCP, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02215408 (MEDication Focused Outpatient Care for Underutilization of Secondary Prevention), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02215408 nacompletednot on this map

MEDication Focused Outpatient Care for Underutilization of Secondary Prevention

TypeinterventionalSponsorKorey KenneltyRan2015 to 2018Enrolled402ConditionsDiabetes, Hyperlipidemia, Hypertension, Cardiovascular DiseaseArmsCVRS Intervention
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Korey KenneltyDepartment of Pharmacy Practice and Science, College of Pharmacy.
Christopher S CoffeyDepartment of Biostatistics, College of Public Health.
Gail ArderyDepartment of Pharmacy Practice and Science, College of Pharmacy.
Liz UribeDepartment of Biostatistics, College of Public Health.
Jon YankeyDepartment of Biostatistics, College of Public Health.
Dixie EcklundDepartment of Biostatistics, College of Public Health.
Paul A JamesDepartment of Family Medicine, Roy J. and Lucille A. Carver College of Medicine.
Mark W Vander WegDepartment of Psychology, College of Liberal Arts, the University of Iowa.
Elizabeth A ChrischillesDepartment of Epidemiology, College of Public Health.
Alan J ChristensenDepartment of Psychology, College of Liberal Arts, the University of Iowa.
Linnea A PolgreenDepartment of Pharmacy Practice and Science, College of Pharmacy.
Brian GryzlakDepartment of Epidemiology, College of Public Health.
Barry L CarterDepartment of Pharmacy Practice and Science, College of Pharmacy.
University of Iowa · USUniversity of Washington · US

Funding

MEDication Focused Outpatient Care for Underutilization of Secondary PreventionR18HL116259 · NHLBI · UNIVERSITY OF IOWA · PI COFFEY, CHRISTOPHER S., KENNELTY, KOREY A · 2014 to 2018
$8.8M
Improved Cardiovascular Risk Reduction to Enhance Rural Primary Care:I-CARER01HL116311 · NHLBI · UNIVERSITY OF IOWA · PI KENNELTY, KOREY A, LEVY, BARCEY THURSTON · 2013 to 2017
$3.6M
NHLBI NIH HHS R01 HL116311NHLBI NIH HHS R18 HL116259
6 · The paper itself

Abstract

Background: We developed a remote cardiovascular risk service (CVRS) managed by clinical pharmacists to support primary care teams. The purpose of this study was to examine whether the CVRS could improve guideline adherence in primary care clinics with diverse geographic and patient characteristics. Methods: This study was a cluster-randomized trial initiated in 20 primary care clinics across the US. Clinics were stratified as high or low minority and then randomized to receive the intervention or maintain usual care for 12 months. The primary outcome was adherence to relevant The Guideline Advantage (TGA) criteria met. TGA is a compilation of criteria from practice guidelines intended to improve the quality of primary care. Post-hoc outcomes included changes in individual TGA measures. Results: A total of 401 study subjects were included in the analysis. Mean TGA scores remained the same in the intervention group (n=193, 0.72) and slightly decreased in the usual care group (n=208, 0.67 to 0.66) over the 12-month study period. There was no significant difference between the mean TGA scores in intervention and usual care groups for the overall population at 12 months (0.72 versus 0.66 respectively, p=0.10). For under-represented minority subjects, there was no significant difference between TGA scores at 12 months (n=186; 0.70 versus 0.67, respectively, p=0.50). In a post-hoc analysis of subjects uncontrolled at baseline, there was a significant improvement in systolic BP at 12 months in the intervention group versus usual care (model-based difference of -8.03mmHg, p=0.03). Conclusions: Improvements in individual TGA measures were limited, in part, due to higher than expected baseline TGA scores. Future studies of this model should focus on patients with uncontrolled conditions at high risk for cardiovascular events. Clinical Trial Registration: ClinicalTrials.gov Identifier: NCT02215408; https://clinicaltrials.gov/ct2/show/NCT02215408?id=NCT02215408.

Indexed as

clinical studieshealth serviceshigh blood pressurehypertensiontranslational studies

Identifiers

PMID37265855
PMCPMC10234512
OpenAlexW3181389102

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.