Evidence map›Paper›PMID 37265775›Full record

ReviewChinese herbal medicines2023

Pharmacological importance of Kunxian Capsule in clinical applications and its adverse effects: A review.

Ruijiao Ma, Maharajan Kannan, Kaiyan Zhuang, Qing Xia, Dong Sun, Pengfei Tu, Taiping Fan, Kechun Liu, Yun Zhang

Abstract readReview
In one paragraph

Review in Chinese herbal medicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ruijiao MaBiology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
Maharajan KannanBiology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
Kaiyan ZhuangBiology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
Qing XiaBiology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
Dong SunGuangzhou Baiyunshan Chenliji Pharmaceutical Factory Co., Ltd., Guangzhou 510288, China.
Pengfei TuState Key Laboratory of Natural Medicines and Biomimetic Medicines, School of Pharmacy, Peking University, Beijing 100191, China.
Taiping FanAngiogenesis and Chinese Medicine Laboratory, Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK.
Kechun LiuBiology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
Yun ZhangBiology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kunxian Capsule (KX) is a popular Chinese patent medicine for the treatment of rheumatoid arthritis, nephrotic syndrome, systemic lupus erythematosus, Henoch-Schönlein purpura, ankylosing spondylitis, psoriatic arthritis and eczema. However, there is scarcity of comprehensive information on the significance of KX in the clinical application and its side effects. Hence, it is aimed to provide a review of the significance of KX, with a focus on the pharmacological effects, clinical applications, and its adverse reactions. This review was based on the published literatures in PubMed, China National Knowledge Infrastructure and WanFang database. The articles were collected by two independent authors with no time limits applied until November 30, 2022. The search term includes Kunxian Capsule and/or clinical effect, pharmacology, disease, therapy, adverse effects and quality control. KX has been shown to be effective in the treatment of autoimmune arthritis by inhibiting inflammatory responses and inducing apoptosis. Many studies suggest that KX has anti-inflammatory and analgesic properties that aid in the improvement of joint functions. KX dispels wind, removes dampness, invigorates the kidneys, and promotes blood circulation, thereby curing various diseases. However, studies also suggest KX-related adverse reactions in multiple systems. Overall, this review highlights the scientific basis of KX in curing or preventing various diseases and provides novel insights for further research and clinical applications.

Indexed as

adverse effectsautoimmune diseaseChinese patent medicineKunxian Capsulerheumatoid arthritis

Identifiers

PMID37265775
PMCPMC10230640

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.