Evidence map›Paper›PMID 37265715›Full record

ArticleChemical science2023

Late-stage peptide labeling with near-infrared fluorogenic nitrobenzodiazoles by manganese-catalyzed C-H activation.

Tsuyoshi Oyama, Lorena Mendive-Tapia, Verity Cowell, Adelina Kopp, Marc Vendrell, Lutz Ackermann

Open access · diamondAbstract read
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Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Tsuyoshi OyamaInstitut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen Tammanstraße 2 37077 Göttingen Germany lutz.ackermann@chemie.uni-goettingen.de.
Lorena Mendive-TapiaCentre for Inflammation Research, The University of Edinburgh EH16 4TJ Edinburgh UK marc.vendrell@ed.ac.uk.ORCID https://orcid.org/0000-0002-3406-5203
Verity CowellCentre for Inflammation Research, The University of Edinburgh EH16 4TJ Edinburgh UK marc.vendrell@ed.ac.uk.
Adelina KoppInstitut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen Tammanstraße 2 37077 Göttingen Germany lutz.ackermann@chemie.uni-goettingen.de.
Marc VendrellCentre for Inflammation Research, The University of Edinburgh EH16 4TJ Edinburgh UK marc.vendrell@ed.ac.uk.ORCID https://orcid.org/0000-0002-5392-9740
Lutz AckermannInstitut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen Tammanstraße 2 37077 Göttingen Germany lutz.ackermann@chemie.uni-goettingen.de.ORCID https://orcid.org/0000-0001-7034-8772
Centre for Inflammation Research · GBUniversity of Göttingen · DEGerman Centre for Cardiovascular Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Late-stage diversification of structurally complex amino acids and peptides provides tremendous potential for drug discovery and molecular imaging. Specifically, labeling peptides with fluorescent tags is one of the most important methods for visualizing their mode of operation. Despite major recent advances in the field, direct molecular peptide labeling by C-H activation is largely limited to dyes with relatively short emission wavelengths, leading to high background signals and poor signal-to-noise ratios. In sharp contrast, here we report on the fluorescent labeling of peptides catalyzed by non-toxic manganese(i)

Identifiers

PMID37265715
PMCPMC10231426
OpenAlexW4372047229

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.