Evidence map›Paper›PMID 37265600›Full record

ArticleBrain communications2023

Compromised white matter is related to lower cognitive performance in adults with phenylketonuria.

Raphaela Muri, Stephanie Maissen-Abgottspon, Murray Bruce Reed, Roland Kreis, Maike Hoefemann, Piotr Radojewski, Katarzyna Pospieszny, Michel Hochuli, Roland Wiest, Rupert Lanzenberger and 2 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06969209 (Brain Aging in Patients With Phenylketonuria), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06969209 recruitingnot on this mapstarted 2025, after this paper: background citation

Brain Aging in Patients With Phenylketonuria

TypeobservationalSponsorInsel Gruppe AG, University Hospital BernRan2025 to 2030Enrolled90ConditionsPhenylketonuria (PKU)
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Brain Age in Adult Patients With Early-Treated Phenylketonuria.Journal of inherited metabolic disease · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Raphaela MuriDepartment of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital and University of Bern, 3010 Bern, Switzerland.
Stephanie Maissen-AbgottsponDepartment of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital and University of Bern, 3010 Bern, Switzerland.
Murray Bruce ReedDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, 1090 Vienna, Austria.
Roland KreisTranslational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, 3010 Bern, Switzerland.ORCID https://orcid.org/0000-0002-8618-6875
Maike HoefemannTranslational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, 3010 Bern, Switzerland.
Piotr RadojewskiSupport Center for Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital and University of Bern, 3010 Bern, Switzerland.
Katarzyna PospiesznySupport Center for Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital and University of Bern, 3010 Bern, Switzerland.
Michel HochuliDepartment of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital and University of Bern, 3010 Bern, Switzerland.
Roland WiestSupport Center for Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital and University of Bern, 3010 Bern, Switzerland.
Rupert LanzenbergerDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, 1090 Vienna, Austria.ORCID https://orcid.org/0000-0003-4641-9539
Roman TreppDepartment of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital and University of Bern, 3010 Bern, Switzerland.
Regula EvertsDepartment of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital and University of Bern, 3010 Bern, Switzerland.ORCID https://orcid.org/0000-0001-6556-3419
University of Bern · CHMedical University of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite increasing knowledge about the effects of phenylketonuria on brain structure and function, it is uncertain whether white matter microstructure is affected and if it is linked to patients' metabolic control or cognitive performance. Thus, we quantitatively assessed white matter characteristics in adults with phenylketonuria and assessed their relationship to concurrent brain and blood phenylalanine levels, historical metabolic control and cognitive performance. Diffusion tensor imaging and

Indexed as

1H spectroscopycerebral white mattercognitiondiffusion tensor imagingphenylketonuria

Identifiers

PMID37265600
PMCPMC10231812
OpenAlexW4376615034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.