ArticleFrontiers in neurology2023
Alterations of brain gray matter volume in children with obstructive sleep apnea.
Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Pediatric OSA-Spectrum of the Disease and Opportunities for Personalized Interventions.Journal of personalized medicine · 2026Review
- Comprehensive Morphometric MRI Assessment in Children with Breath-Holding Spells: Integration of Automated (Vol2Brain) and Semi-Automated (3D Slicer) Segmentation Methods.Tomography (Ann Arbor, Mich.) · 2026Article
- Advances in MRI of glymphatic system dysfunction associated with obstructive sleep apnea and enlarged perivascular spaces.Frontiers in neurology · 2026Review
- Parent Reports Versus Objective Behavioral Measures in Pediatric Sleep-Disordered Breathing.Laryngoscope investigative otolaryngology · 2025Article
- Assessing Executive Function in Pediatric Sleep-Disordered Breathing Using Functional Neuroimaging.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Observational
- Upper Airway Volume Predicts Brain Structure and Cognition in Adolescents.American journal of respiratory and critical care medicine · 2025Article
- [Association Between Obstructive Sleep Apnea and Behavioral Problems in Children].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Article
- Whole Brain Amide Proton Transfer Weighted Imaging in Children With Obstructive Sleep Apnea.Brain and behavior · 2025Article
- Obstructive sleep apnea and structural and functional brain alterations: a brain-wide investigation from clinical association to genetic causality.BMC medicine · 2025Article
- The importance of sleep for the developing brain.Current sleep medicine reports · 2024Article
- Analysis of Cognitive Levels and Influencing Factors in Children with Obstructive Sleep Apnea.Children (Basel, Switzerland) · 2024Article
- Tet1-mediated 5hmC regulates hippocampal neuroinflammation via wnt signaling as a novel mechanism in obstructive sleep apnoea leads to cognitive deficit.Journal of neuroinflammation · 2024Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Obstructive sleep apnea (OSA) seriously affects the children's cognitive functions, but the neuroimaging mechanism of cognitive impairment is still unclear. The purpose of our study was to explore the difference in brain local gray matter volume (GMV) between children with OSA and non-OSA, and the correlation between the difference regions of brain gray matter volume and cognitive, the severity of OSA. Method: Eighty-three children aged 8-13 years were recruited in our study, 52 children were diagnosed as OSA by polysomnography, and 31 as the non-OSA. All the subjects were underwent high-resolution 3-dimensional T1-weighted magnetic resonance images. The voxel-based morphometry (VBM) was be used to analyse the local GMV. The Das-Naglieri cognitive assessment system (DN: CAS) was used to assess the subjects' cognitive. The difference of local GMV between the two groups was analyzed by two-sample Results: The gray matter volume of the right Middle Frontal Gyrus (MFG_R) in OSA children were larger than the non-OSA children, and the OSA children had lower scores of the Word Series in DN: CAS. There was negative correlation between the scores of Expressive Attention in DN: CAS and the gray matter volume of the right middle frontal gyrus, and it was no significantly correlation between OAHI and the gray matter volume of the right middle frontal gyrus. Conclusion: Our results suggest that the development of gray matter volume in frontal cortex, which associated with attention, were sensitive to the effects of OSA, provides neuroimaging evidence for cognitive impairment in children with OSA.
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