ArticleFrontiers in neurology2023
Deficits in the thalamocortical pathway associated with hypersensitivity to pain in patients with frozen shoulder.
Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- Connectomic Mapping of Chronic Musculoskeletal Pain: Neural Circuitries Identified Through a Systematic Review and ALE Meta-Analysis.Neural plasticity · 2026Pooled it
- Peripheral inflammation and central sensitization associated with postoperative pain following arthroscopy surgery in rotator cuff injury.La Radiologia medica · 2026Article
- Abnormal Brain Structure and Function in People with Shoulder Pain: A Systematic Review of Neuroimaging Studies.Journal of pain research · 2026Review
- Neuroplasticity in chronic pain: insights into diagnosis and treatment.The Korean journal of pain · 2025Article
- Effects of rTMS over the contralateral M1 combined with NMES on pain and functional mobility in primary frozen shoulder: study protocol for a 4-week double-blind, randomized, sham-controlled trial.Frontiers in neurology · 2025Article
- Functional Brain Changes in Younger Population of Cervical Spondylosis Patients with Chronic Neck Pain.Journal of pain research · 2024Article
- Machine learning-based evaluation of spontaneous pain and analgesics from cellular calcium signals in the mouse primary somatosensory cortex using explainable features.Frontiers in molecular neuroscience · 2024Article
- Neural correlates of central pain sensitization in chronic low back pain: a resting-state fMRI study.Neuroradiology · 2023Article
Corrections and comments
- Retracted
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and purpose: Frozen shoulder (FS) is a chronic pain condition and has been shown to be associated with pain sensitization. However, the underyling brain mechanisms remain unclear. Here, we aimed to explore brain alterations and their association with pain sensitization in patients with FS. Materials and methods: A total of 54 FS patients and 52 healthy controls (HCs) were included in this study. Here, we applied both structural and functional magnetic resonance imaging (MRI) techniques to investigate brain abnormalities in FS patients. Voxel-wise comparisons were performed to reveal the differences in the gray matter volume (GMV) and amplitude of low-frequency fluctuation (ALFF) between FS patients and HCs. Furthermore, the region of interest (ROI) to whole-brain functional connectivity (FC) was calculated and compared between groups. Finally, Pearson's correlation coefficients were computed to reveal the association between clinical data and brain alterations. Results: Four main findings were observed: (1) FS patients exhibited decreased thalamus GMV, which correlated with pain intensity and pain threshold; (2) relative to HCs, FS patients exhibited a higher level of ALFF within the anterior cingulate cortex (ACC) and the thalamus; (3) FS patients exhibited a significant increase in Tha-S1 FC compared to HCs; and (4) the effect of thalamus GMV on pain intensity was mediated by pain threshold in FS patients. Conclusion: The dysfunctional thalamus might induce pain hypersensitivity, which further aggravates the pain in FS patients.
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