ArticleCerebral cortex (New York, N.Y. : 1991)2023
Memory reactivation and suppression modulate integration of the semantic features of related memories in hippocampus.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- The human hippocampus can pattern separate memories by meaning.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The hippocampus rapidly integrates sequence representations during novel multistep predictions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
- Stress disrupts hippocampal integration of overlapping events and memory inference in humans.Science advances · 2026Article
- Not the same as it ever was: A review of memory modification, updating, and distortion in humans and rodents.Neuroscience and biobehavioral reviews · 2025Review
- The role of memory in affirming-the-consequent fallacy.iScience · 2025Article
- Efficacy of Acupuncture Therapy in Treating Non-Motor Symptoms of Parkinson's Disease: A Systematic Review and Network Meta-Analysis.Neuropsychiatric disease and treatment · 2025Review
- Semantic relatedness proactively benefits learning, memory, and interdependence across episodes.eLife · 2024Article
- Discrimination of semantically similar verbal memory traces is affected in healthy aging.Scientific reports · 2024Article
- Predictability Changes What We Remember in Familiar Temporal Contexts.Journal of cognitive neuroscience · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Encoding an event that overlaps with a previous experience may involve reactivating an existing memory and integrating it with new information or suppressing the existing memory to promote formation of a distinct, new representation. We used fMRI during overlapping event encoding to track reactivation and suppression of individual, related memories. We further used a model of semantic knowledge based on Wikipedia to quantify both reactivation of semantic knowledge related to a previous event and formation of integrated memories containing semantic features of both events. Representational similarity analysis revealed that reactivation of semantic knowledge related to a prior event in posterior medial prefrontal cortex (pmPFC) supported memory integration during new learning. Moreover, anterior hippocampus (aHPC) formed integrated representations combining the semantic features of overlapping events. We further found evidence that aHPC integration may be modulated on a trial-by-trial basis by interactions between ventrolateral PFC and anterior mPFC, with suppression of item-specific memory representations in anterior mPFC inhibiting hippocampal integration. These results suggest that PFC-mediated control processes determine the availability of specific relevant memories during new learning, thus impacting hippocampal memory integration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.