Evidence map›Paper›PMID 37264823›Full record

ArticleCancer discovery2023

Melanoma Genomics: Shifting Focus from Inter- to Intrapatient Variation.

A Hunter Shain

Abstract readEditorialComment
PubMed Publisher
In one paragraph

Article in Cancer discovery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

A Hunter ShainDepartment of Dermatology, University of California San Francisco, San Francisco, California.ORCID 0000-0002-2999-9706

Funding

The genomic landscape and evolution of cutaneous squamous cell carcinomaR01CA265786 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alan Hunter Shain · 2022 to 2026
$2.1M
The mutational mechanisms shaping melanocytes in human skinR01AR080626 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alan Hunter Shain · 2023 to 2026
$1.6M
NCI NIH HHS R01 CA265786NIAMS NIH HHS R01 AR080626
6 · The paper itself

Abstract

summaryTraditionally, omic studies have prioritized the number of patients over the number of tumors per patient, but in a reversal of this study design, Spain and colleagues performed the largest intrapatient analysis of melanoma to date. Their work reveals mechanisms of treatment resistance, patterns of metastatic dissemination, and new insights into the evolutionary trajectories of melanoma. See related article by Spain et al., p. 1364 (1).

Indexed as

MelanomaNeoplasms, Second PrimaryBiological EvolutionGenomicsHumans

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.