Evidence map›Paper›PMID 37264424›Full record

ReviewBiotechnology for biofuels and bioproducts2023

Alcohol acyltransferases for the biosynthesis of esters.

Gaofei Liu, Lei Huang, Jiazhang Lian

Open access · goldAbstract readReview
In one paragraph

Review in Biotechnology for biofuels and bioproducts, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 37 citations in OpenAlex.

  1. Calcium-Triggered PuMYB44-PuERF118 Cascade ActivatesInternational journal of molecular sciences · 2026
    Article
  2. Fermentation Strategy and Non-Foods (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Multi-layered metabolic remodeling ofMetabolic engineering communications · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Effect of Intensified Fermentation withFoods (Basel, Switzerland) · 2025
    Article
  14. Review
  15. Article
  16. Article
  17. Genome Sequencing, Assembly, and Characterization ofJournal of fungi (Basel, Switzerland) · 2025
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Gaofei LiuKey Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China.
Lei HuangKey Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China.
Jiazhang LianKey Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China. jzlian@zju.edu.cn.
Zhejiang University of Science and Technology · CNZhejiang University · CN

Funding

National Key Research and Development Program of China 2021YFC2103200Natural Science Foundation of China 22278361Natural Science Foundation of Zhejiang Province LR20B060003the Fundamental Research Funds for the Central Universities 226-2022-00214the Fundamental Research Funds for the Central Universities 226-2023-00015the Fundamental Research Funds for the Central Universities 226-2023-00085
6 · The paper itself

Abstract

Esters are widely used in food, energy, spices, chemical industry, etc., becoming an indispensable part of life. However, their production heavily relies on the fossil energy industry, which presents significant challenges associated with energy shortages and environmental pollution. Consequently, there is an urgent need to identify alternative green methods for ester production. One promising solution is biosynthesis, which offers sustainable and environmentally friendly processes. In ester biosynthesis, alcohol acyltransferases (AATs) catalyze the condensation of acyl-CoAs and alcohols to form esters, enabling the biosynthesis of nearly 100 different kinds of esters, such as ethyl acetate, hexyl acetate, ethyl crotonate, isoamyl acetate, and butyl butyrate. However, low catalytic efficiency and low selectivity of AATs represent the major bottlenecks for the biosynthesis of certain specific esters, which should be addressed with protein molecular engineering approaches before practical biotechnological applications. This review provides an overview of AAT enzymes, including their sequences, structures, active sites, catalytic mechanisms, and metabolic engineering applications. Furthermore, considering the critical role of AATs in determining the final ester products, the current research progresses of AAT modification using protein molecular engineering are also discussed. This review summarized the major challenges and prospects of AAT enzymes in ester biosynthesis.

Indexed as

Alcohol acyltransferaseEster biosynthesisMetabolic engineeringProtein engineeringSynthetic biology

Identifiers

PMID37264424
PMCPMC10236719
OpenAlexW4378975971

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.