ArticleBMC endocrine disorders2023
Sensitivity to thyroid hormone indices are associated with papillary thyroid carcinoma in Chinese patients with thyroid nodules.
Article in BMC endocrine disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Sociodemographic and clinical predictors of malignancy in thyroid nodules: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Subclinical myocardial dysfunction in treatment naive papillary thyroid carcinoma patients.Scientific reports · 2026Article
- The FT4/FT3 ratio combined with thyroglobulin and parathyroid hormone for distinguishing benign from malignant thyroid nodules: a retrospective study based on histopathological diagnosis.Frontiers in medicine · 2026Article
- Elevated mitochondrial DNA copy number in euthyroid individuals with impaired peripheral sensitivity to thyroid hormones.Frontiers in endocrinology · 2025Article
- Reduced sensitivity to thyroid hormones is associated with differentiated thyroid cancer in the euthyroid thyroidectomy population.Frontiers in endocrinology · 2025Article
- Association Between FT4/FT3 Ratio and Short-Term Treatment Response in Differentiated Thyroid Cancer Patients.International journal of endocrinology · 2025Article
- Association between impaired sensitivity to thyroid hormones and sedentary behavior: a cross-sectional study.Frontiers in medicine · 2025Article
- Association between thyroid stimulating hormone levels and papillary thyroid cancer risk: A meta-analysis.Open life sciences · 2023Article
- Prediction Model of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma.Cancer control : journal of the Moffitt Cancer CenterArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe association between thyroid hormone sensitivity and thyroid cancer is unknown, and we aimed to investigate the association between sensitivity to thyroid hormone indices and papillary thyroid carcinoma (PTC) in Chinese patients with thyroid nodules (TNs).
methodsA total of 1,998 patients undergoing thyroid surgery due to TNs from Nanjing Drum Tower Hospital were included in this study. We evaluated central sensitivity to thyroid hormones, such as thyroid stimulating hormone index (TSHI), TSH T4 resistance index (TT4RI), thyroid feedback quantile-based index (TFQI), and parametric thyroid feedback quantile-based Index (PTFQI). Peripheral sensitivity to thyroid hormone was evaluated by FT3 to FT4 ratio. Multivariate logistic regression analysis was performed to evaluate the association between sensitivity to thyroid hormone indices and PTC risk.
resultsThe results showed that central indices of thyroid hormone sensitivity, including TSHI, TT4RI, TFQI, and PTFQI, were positively associated with PTC risk. For each SD increase in TSHI, TT4RI, TFQI, and PTFQI, the odds ratios (OR, 95% CI) of PTC were 1.31 (1.18-1.46), 1.01 (1.01-1.02), 1.94 (1.45-2.60), and 1.82 (1.41-2.34), respectively. On the other hand, the association between peripheral sensitivity to thyroid hormone and PTC was significantly negative. For each SD increase in FT3/FT4 ratio, the OR (95% CI) of PTC was 0.18 (0.03-0.96), and a negative correlation was found between FT3/FT4 ratio and TNM staging of PTC.
conclusionsSensitivity to thyroid hormone indices could be used as new indicators for predicting PTC in Chinese patients with TNs. Future researches are still needed to confirm our findings.
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