Evidence map›Paper›PMID 37264147›Full record

ArticleNature methods2023

ReX: an integrative tool for quantifying and optimizing measurement reliability for the study of individual differences.

Ting Xu, Gregory Kiar, Jae Wook Cho, Eric W Bridgeford, Aki Nikolaidis, Joshua T Vogelstein, Michael P Milham

Abstract read
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In one paragraph

Article in Nature methods, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Challenges in measuring individual differences of brain function.Imaging neuroscience (Cambridge, Mass.) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ting XuDepartment of Brain Development, Child Mind Institute, New York, NY, USA. ting.xu@childmind.org.ORCID http://orcid.org/0000-0002-0065-3832
Gregory KiarDepartment of Brain Development, Child Mind Institute, New York, NY, USA.ORCID http://orcid.org/0000-0001-8915-496X
Jae Wook ChoDepartment of Brain Development, Child Mind Institute, New York, NY, USA.
Eric W BridgefordJohns Hopkins University, Baltimore, MD, USA.
Aki NikolaidisDepartment of Brain Development, Child Mind Institute, New York, NY, USA.
Joshua T VogelsteinJohns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-2487-6237
Michael P MilhamDepartment of Brain Development, Child Mind Institute, New York, NY, USA.ORCID http://orcid.org/0000-0003-3532-1210

Funding

The NKI Rockland Sample II: An Open Resource of Multimodal Brain, Physiology & Behavior Data from a Community Lifespan SampleR01MH124045 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI COLCOMBE, STAN J, MILHAM, MICHAEL PETER · 2021 to 2025
$3.7M
Reproducible imaging-based brain growth charts for psychiatryR01MH120482 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI MILHAM, MICHAEL PETER, SATTERTHWAITE, THEODORE · 2019 to 2023
$3.5M
C-PAC: A configurable, compute-optimized, cloud-enabled neuroimaging analysis software for reproducible translational and comparativeR24MH114806 · NIMH · CHILD MIND INSTITUTE, INC. · PI CRADDOCK, RICHARD CAMERON, MILHAM, MICHAEL PETER · 2018 to 2020
$1.6M
An Alignment Framework For Mapping Brain Dynamics and Substrates of Human Cognition Across SpeciesRF1MH128696 · NIMH · CHILD MIND INSTITUTE, INC. · PI XU, TING · 2021 to 2021
$1.2M
NIMH NIH HHS R01 MH120482NIMH NIH HHS R01 MH124045NIMH NIH HHS R24 MH114806NIMH NIH HHS RF1 MH128696
6 · The paper itself

Abstract

Characterizing multifaceted individual differences in brain function using neuroimaging is central to biomarker discovery in neuroscience. We provide an integrative toolbox, Reliability eXplorer (ReX), to facilitate the examination of individual variation and reliability as well as the effective direction for optimization of measuring individual differences in biomarker discovery. We also illustrate gradient flows, a two-dimensional field map-based approach to identifying and representing the most effective direction for optimization when measuring individual differences, which is implemented in ReX.

Indexed as

IndividualityNeuroimagingBiomarkersReproducibility of ResultsBiomarkers

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.