Evidence map›Paper›PMID 37264140›Full record

ArticleNature structural & molecular biology2023

Structural basis for control of bacterial RNA polymerase pausing by a riboswitch and its ligand.

Adrien Chauvier, Jason C Porta, Indrajit Deb, Emily Ellinger, Katarina Meze, Aaron T Frank, Melanie D Ohi, Nils G Walter

Abstract read
In one paragraph

Article in Nature structural & molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  11. FRET-guided modeling of nucleic acids.Nucleic acids research · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adrien Chauvier *Single Molecule Analysis Group and Center for RNA Biomedicine, Department of Chemistry, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-4473-6194
Jason C Porta *Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Indrajit DebBiophysics Program, University of Michigan, Ann Arbor, MI, USA.
Emily EllingerSingle Molecule Analysis Group and Center for RNA Biomedicine, Department of Chemistry, University of Michigan, Ann Arbor, MI, USA.
Katarina MezeSingle Molecule Analysis Group and Center for RNA Biomedicine, Department of Chemistry, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-0849-9304
Aaron T FrankBiophysics Program, University of Michigan, Ann Arbor, MI, USA.
Melanie D OhiLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA. mohi@umich.edu.ORCID 0000-0003-1750-4793
Nils G WalterSingle Molecule Analysis Group and Center for RNA Biomedicine, Department of Chemistry, University of Michigan, Ann Arbor, MI, USA. nwalter@umich.edu.ORCID 0000-0002-7301-1275

Funding

Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
The RNA nanomachines of the gene expression machinery dissected at the single molecule levelR35GM131922 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NILS G WALTER · 2019 to 2026
$6.9M
Developmental Mechanisms for the Evolution of Bone LossR01AG031922 · NIA · UNIVERSITY OF OREGON · PI POSTLETHWAIT, JOHN H. · 2008 to 2012
$2.4M
Cotranscriptional folding of single riboswitchesR01GM118524 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WALTER, NILS G · 2016 to 2018
$911k
Compute Cluster for in vitro and in situ Analysis of Molecular MachinesS10OD030275 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OHI, MELANIE DIANE · 2021 to 2021
$600k
Silicon Mechanics Compute ClusterS10OD020011 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SKINIOTIS, GEORGIOS · 2015 to 2015
$490k
NIA NIH HHS R01 AG031922NIGMS NIH HHS P41 GM103311NIGMS NIH HHS R01 GM118524NIGMS NIH HHS R35 GM131922NIH HHS S10 OD020011NIH HHS S10 OD030275
6 · The paper itself

Abstract

Folding of nascent transcripts can be modulated by the RNA polymerase (RNAP) that carries out their transcription, and vice versa. A pause of RNAP during transcription of a preQ

Indexed as

Escherichia coli ProteinsRiboswitchBacteriaCryoelectron MicroscopyDNA-Directed RNA PolymerasesLigandsNucleic Acid ConformationRNA, BacterialRNA FoldingTranscription, GeneticDNA-Directed RNA PolymerasesEscherichia coli ProteinsLigandsRiboswitchRNA, Bacterial

Identifiers

PMID37264140
PMCPMC10523900

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.