Evidence map›Paper›PMID 37264112›Full record

ArticleScientific reports2023

Heterogeneity of voltage gated sodium current density between neurons decorrelates spiking and suppresses network synchronization in Scn1b null mouse models.

Jacob M Hull, Nicholas Denomme, Yukun Yuan, Victoria Booth, Lori L Isom

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jacob M HullNeuroscience Graduate Program, University of Michigan, Ann Arbor, MI, 48109, USA.
Nicholas DenommeDepartment of Pharmacology, University of Michigan, Ann Arbor, MI, 48109, USA.
Yukun YuanDepartment of Pharmacology, University of Michigan, Ann Arbor, MI, 48109, USA.
Victoria BoothNeuroscience Graduate Program, University of Michigan, Ann Arbor, MI, 48109, USA.
Lori L IsomNeuroscience Graduate Program, University of Michigan, Ann Arbor, MI, 48109, USA. lisom@umich.edu.
University of Michigan · USMichigan Medicine · US

Funding

Role of SCN1B in Inherited EpilepsyR37NS076752 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ISOM, LORI L. · 2017 to 2023
$4.8M
NINDS NIH HHS R37 NS076752
6 · The paper itself

Abstract

Voltage gated sodium channels (VGSCs) are required for action potential initiation and propagation in mammalian neurons. As with other ion channel families, VGSC density varies between neurons. Importantly, sodium current (I

Indexed as

NeuronsSodiumAction PotentialsAnimalsMammalsMiceMice, KnockoutReproducibility of ResultsTetrodotoxinVoltage-Gated Sodium Channel beta-1 SubunitScn1b protein, mouseSodiumTetrodotoxinVoltage-Gated Sodium Channel beta-1 Subunit

Identifiers

PMID37264112
PMCPMC10235421
OpenAlexW4379052668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.