Evidence map›Paper›PMID 37264110›Full record

ArticleScientific reports2023

Epigenomic landscape exhibits interferon signaling suppression in the patient of myocarditis after BNT162b2 vaccination.

Hyeonhui Kim, Hyo-Suk Ahn, Nahee Hwang, Yune Huh, Seonghyeon Bu, Kyung Jin Seo, Se Hwan Kwon, Hae-Kyung Lee, Jae-Woo Kim, Bo Kyung Yoon and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Hyeonhui Kim *Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, 03722, Korea.
Hyo-Suk Ahn *Division of Cardiology, Department of Internal Medicine, The Catholic University of Korea, Uijeongbu St. Mary's Hospital, Seoul, 06591, Korea.
Nahee HwangGraduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, 03722, Korea.
Yune HuhDepartment of Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Seonghyeon BuDivision of Cardiology, Department of Internal Medicine, The Catholic University of Korea, Uijeongbu St. Mary's Hospital, Seoul, 06591, Korea.
Kyung Jin SeoDepartment of Hospital Pathology, College of Medicine, The Catholic University of Korea, Uijeongbu St. Mary's Hospital, Seoul, South Korea.
Se Hwan KwonDepartment of Radiology, Kyung Hee University Medical Center, Seoul, South Korea.
Hae-Kyung LeeSeverance Biomedical Science Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, 03722, Korea.
Jae-Woo KimDepartment of Biochemistry and Molecular Biology, Yonsei University College of Medicine, Seoul, 03722, Korea.
Bo Kyung YoonDepartment of Biochemistry and Molecular Biology, Yonsei University College of Medicine, Seoul, 03722, Korea. yoonbbk89@yuhs.ac.
Sungsoon FangGraduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, 03722, Korea. sfang@yuhs.ac.
Yonsei University · KRGangnam Severance Hospital · KRThe Catholic University of Korea Uijeongbu St. Mary's Hospital · KRCatholic University of Korea · KRKyung Hee University Medical Center · KRYonsei University Health System · KR

Funding

PROVIDE RABBITS, RATS MICE, HAMSTERS GERBILS, GUINEA PIGS27307C0012 · NIEHS · PI BOLEN, WAYNE · 2007 to 2007
$1.0M
NIEHS NIH HHS 27307C0012
6 · The paper itself

Abstract

After the outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, a novel mRNA vaccine (BNT162b2) was developed at an unprecedented speed. Although most countries have achieved widespread immunity from vaccines and infections, yet people, even who have recovered from SARS-CoV-2 infection, are recommended to receive vaccination due to their effectiveness in lowering the risk of recurrent infection. However, the BNT162b2 vaccine has been reported to increase the risk of myocarditis. To our knowledge, for the first time in this study, we tracked changes in the chromatin dynamics of peripheral blood mononuclear cells (PBMCs) in the patient who underwent myocarditis after BNT162b2 vaccination. A longitudinal study of chromatin accessibility using concurrent analysis of single-cell assays for transposase-accessible chromatin with sequencing and single-cell RNA sequencing showed downregulation of interferon signaling and upregulated RUNX2/3 activity in PBMCs. Considering BNT162b2 vaccination increases the level of interferon-α/γ in serum, our data highlight the immune responses different from the conventional responses to the vaccination, which is possibly the key to understanding the side effects of BNT162b2 vaccination.

Indexed as

COVID-19MyocarditisAntibodies, ViralBNT162 VaccineChromatinEpigenomicsHumansInterferon-alphaInterferon-gammaLeukocytes, MononuclearLongitudinal StudiesSARS-CoV-2VaccinationAntibodies, ViralBNT162 VaccineChromatinInterferon-alphaInterferon-gamma

Identifiers

PMID37264110
PMCPMC10234245
OpenAlexW4379055570

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.