Evidence map›Paper›PMID 37264016›Full record

ArticleNature communications2023

The blood proteome of imminent lung cancer diagnosis.

Lung Cancer Cohort Consortium (LC3)

Abstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed.

  1. Review
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  17. Article
  18. Advances in the Basic Sciences in Thoracic Oncology in the Last 20 Years and Their Translational Impact.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2026
    Review
  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Lung Cancer Cohort Consortium (LC3)

Funding

Translating Molecular and Clinical Data to Population Lung Cancer Risk AssessmentU19CA203654 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Christopher I. Amos, Rayjean J. Hung · 2017 to 2026
$23.7M
Prospective studies of cancer etiology and prevention in Shanghai and SingaporeR01CA144034 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2010 to 2014
$7.0M
THE SINGAPORE COHORT STUDY OF DIET AND CANCERR01CA080205 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YUAN, JIAN-MIN · 1999 to 2009
$5.3M
The Lung EArly Proteins project: A LEAP toward implementing biomarkers in lung cancer screeningR01CA262164 · NCI · INTERNATIONAL AGENCY FOR RES ON CANCER · PI ROBBINS, HILARY A. · 2022 to 2025
$2.0M
Evaluating risk prediction models for use in lung cancer screening in diverse populations around the worldR03CA245979 · NCI · INTERNATIONAL AGENCY FOR RES ON CANCER · PI ROBBINS, HILARY A. · 2020 to 2020
$112k
Cancer Research UK 14136Cancer Research UK 29017Cancer Research UK C18281/A29019Cancer Research UK C8221/A29017Medical Research Council 1000143Medical Research Council MR/M012190/1NCI NIH HHS R01 CA080205NCI NIH HHS R01 CA144034NCI NIH HHS R01 CA262164NCI NIH HHS R03 CA245979NCI NIH HHS U19 CA203654
6 · The paper itself

Abstract

Identification of risk biomarkers may enhance early detection of smoking-related lung cancer. We measured between 392 and 1,162 proteins in blood samples drawn at most three years before diagnosis in 731 smoking-matched case-control sets nested within six prospective cohorts from the US, Europe, Singapore, and Australia. We identify 36 proteins with independently reproducible associations with risk of imminent lung cancer diagnosis (all p < 4 × 10

Indexed as

Lung NeoplasmsProteomeBiomarkers, TumorCase-Control StudiesHumansInsulin-Like Growth Factor Binding Protein 1Prospective StudiesRisk FactorsBiomarkers, TumorInsulin-Like Growth Factor Binding Protein 1Proteome

Identifiers

PMID37264016
PMCPMC10235023

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.