ArticleJournal of neurology, neurosurgery, and psychiatry2023
Evoked mid-frontal activity predicts cognitive dysfunction in Parkinson's disease.
Article in Journal of neurology, neurosurgery, and psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06984757 (Mid-frontal Delta/Theta and Cognitive Control), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mid-frontal Delta/Theta and Cognitive Control
Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Time-Varying Effective Network of Rehabilitation in Parkinson's Disease With Disease Laterality: A TMS-EEG Study.CNS neuroscience & therapeutics · 2026Article
- Male mice are particularly vulnerable to cognitive impairment following mTBI.bioRxiv : the preprint server for biology · 2026Article
- Parkinson's and Alzheimer's disease impairs temporal precision.Research square · 2026Article
- Disruption of low-frequency narrowband EEG microstate networks in Parkinson's disease with mild cognitive impairment.Journal of neuroengineering and rehabilitation · 2025Article
- Amphetamine increases timing variability by degrading prefrontal temporal encoding.Neuropharmacology · 2025Article
- Neural transmission in the wired brain, new insights into an encoding-decoding-based neuronal communication model.Translational psychiatry · 2025Article
- Dopaminergic modulation of behavioral and electrocortical markers of interpersonal performance monitoring in Parkinson's Disease.Communications biology · 2025Article
- A Multi-omics Framework Based on Machine Learning as a Predictor of Cognitive Impairment Progression in Early Parkinson's Disease.Neurology and therapy · 2025Article
- Cerebellar Oscillatory Patterns in Essential Tremor: Modulatory Effects of VIM-DBS.Cerebellum (London, England) · 2025Article
- Resting state electroencephalography alpha activity predicts cognitive scores in rapid eye movement sleep behavior disorder.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Linear predictive coding electroencephalography algorithms predict mortality in Parkinson's disease.Clinical parkinsonism & related disorders · 2025Article
- Cognition falters at ~4 Hz in Parkinson's disease.Trends in cognitive sciences · 2024Article
- Resting-state EEG measures cognitive impairment in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Mild cognitive impairment in Parkinson's disease: current view.Frontiers in cognition · 2024Review
- Pathobiology of Cognitive Impairment in Parkinson Disease: Challenges and Outlooks.International journal of molecular sciences · 2023Review
- Salience network and cognitive impairment in Parkinson's disease.medRxiv : the preprint server for health sciences · 2023Article
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Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCognitive dysfunction is a major feature of Parkinson's disease (PD), but the pathophysiology remains unknown. One potential mechanism is abnormal low-frequency cortical rhythms which engage cognitive functions and are deficient in PD. We tested the hypothesis that mid-frontal delta/theta rhythms predict cognitive dysfunction in PD.
methodWe recruited 100 patients with PD and 49 demographically similar control participants who completed a series of cognitive control tasks, including the Simon, oddball and interval-timing tasks. We focused on cue-evoked delta (1-4 Hz) and theta (4-7 Hz) rhythms from a single mid-frontal EEG electrode (cranial vertex (Cz)) in patients with PD who were either cognitively normal, with mild-cognitive impairments (Parkinson's disease with mild-cognitive impairment) or had dementia (Parkinson's disease dementia).
resultsWe found that PD-related cognitive dysfunction was associated with increased response latencies and decreased mid-frontal delta power across all tasks. Within patients with PD, the first principal component of evoked electroencephalography features from a single electrode (Cz) strongly correlated with clinical metrics such as the Montreal Cognitive Assessment score (r=0.34) and with National Institutes of Health Toolbox Executive Function score (r=0.46).
conclusionsThese data demonstrate that cue-evoked mid-frontal delta/theta rhythms directly relate to cognition in PD. Our results provide insight into the nature of low-frequency frontal rhythms and suggest that PD-related cognitive dysfunction results from decreased delta/theta activity. These findings could facilitate the development of new biomarkers and targeted therapies for cognitive symptoms of PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.