Evidence map›Paper›PMID 37263295›Full record

ArticleNeuropediatrics2023

Observation of a Possible Successful Treatment of DEPDC5-Related Epilepsy with mTOR Inhibitor.

Kinga Hadzsiev, Márta Hegyi, András Fogarasi, Tímea Bodó-Baltavári, Anna Zsigmond, Anita Maász, András Szabó, Ágnes Till

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kinga HadzsievDepartment of Medical Genetics, Medical School, Clinical Center, University of Pécs, Pécs, Hungary.
Márta HegyiBethesda Children's Hospital, Epilepsy Center, Budapest, Hungary.
András FogarasiBethesda Children's Hospital, Epilepsy Center, Budapest, Hungary.
Tímea Bodó-BaltaváriBethesda Children's Hospital, Epilepsy Center, Budapest, Hungary.
Anna ZsigmondDepartment of Medical Genetics, Medical School, Clinical Center, University of Pécs, Pécs, Hungary.
Anita MaászDepartment of Medical Genetics, Medical School, Clinical Center, University of Pécs, Pécs, Hungary.
András SzabóDepartment of Medical Genetics, Medical School, Clinical Center, University of Pécs, Pécs, Hungary.
Ágnes TillDepartment of Medical Genetics, Medical School, Clinical Center, University of Pécs, Pécs, Hungary.ORCID 0000-0003-4166-755X
University of Pecs · HUBethesda Gyermekkórház · HU

Funding

Medical School of University of Pécs, "ÁOK-KA" Research Program KA-2021-13
6 · The paper itself

Abstract

The mechanistic target of the rapamycin signaling pathway serves as a central regulator of cell metabolism, growth, proliferation, and survival. In its regulation, the GTPase-activating protein activity toward Rags1 complex has an inhibitory effect. Mutations in genes encoding this complex protein are among the most common abnormalities in focal epilepsies. Within these mutations, the mutations affecting the

Indexed as

Epilepsies, PartialEpilepsyEpilepsy, GeneralizedGTPase-Activating ProteinsHumansMTOR InhibitorsSeizuresTOR Serine-Threonine KinasesDEPDC5 protein, humanGTPase-Activating ProteinsMTOR InhibitorsTOR Serine-Threonine Kinases

Identifiers

PMID37263295
PMCPMC10506865
OpenAlexW4379056635

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.