Evidence map›Paper›PMID 37263126›Full record

ArticlePsychiatry research. Neuroimaging2023

Heightened adolescent emotional reactivity in the brain is associated with lower future distress tolerance and higher depressive symptoms.

Amanda C Del Giacco, Scott A Jones, Kristina O Hernandez, Samantha J Barnes, Bonnie J Nagel

Open access · greenAbstract read
In one paragraph

Article in Psychiatry research. Neuroimaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Amanda C Del GiaccoDepartments of Psychiatry, Oregon Health & Science University, Portland, OR, United States of America.
Scott A JonesDepartments of Psychiatry, Oregon Health & Science University, Portland, OR, United States of America.
Kristina O HernandezDepartments of Psychiatry, Oregon Health & Science University, Portland, OR, United States of America.
Samantha J BarnesDepartments of Psychiatry, Oregon Health & Science University, Portland, OR, United States of America.
Bonnie J NagelDepartments of Psychiatry, Oregon Health & Science University, Portland, OR, United States of America; Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon, United States of America. Electronic address: nagelb@ohsu.edu.
Oregon Health & Science University · US

Funding

Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
BIOLOGICAL BASES OF ALCOHOLISMT32AA007468 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Andrey E Ryabinin · 1987 to 2026
$11.3M
Oregon Clinical and Translational Research Institute TL1 ProgramTL1TR002371 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ALLISON Deborah FRYER, JESSINA C MCGREGOR · 2017 to 2026
$6.2M
Timing Effects of Heavy Alcohol Initiation on Adolescent NeurodevelopmentR01AA017664 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI NAGEL, BONNIE J · 2009 to 2020
$3.7M
A Prisma Upgrade for the OHSU Advanced Imaging Research Center 3T MRI InstrumentS10OD021701 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI ROONEY, WILLIAM D · 2016 to 2016
$1.6M
Comparing reward learning among adolescents and adults with MDD and using reward-related neurobiology to predict future reward-related learningF31MH131268 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI DEL GIACCO, AMANDA C · 2023 to 2024
$76k
NCATS NIH HHS TL1 TR002371NCATS NIH HHS UL1 TR002369NIAAA NIH HHS R01 AA017664NIAAA NIH HHS T32 AA007468NIH HHS S10 OD021701NIMH NIH HHS F31 MH131268
6 · The paper itself

Abstract

Distress tolerance, the ability to persist while experiencing negative psychological states, is essential for regulating emotions and is a transdiagnostic risk/resiliency trait for multiple psychopathologies. Studying distress tolerance during adolescence, a period when emotion regulation is still developing, may help identify early risk and/or protective factors. This study included 40 participants (mean scan age = 17.5 years) and using an emotional Go-NoGo functional magnetic resonance imaging task and voxel-wise regression analysis, examined the association between brain response during emotional face processing and future distress tolerance (two ± 0.5 years), controlling for sex assigned at birth, age, and time between visits. Post-hoc analyses tested the mediating role of distress tolerance on the emotional reactivity and depressive symptom relationship. Whole-brain analysis showed greater inferior occipital gyrus activation was associated with less distress tolerance at follow-up. The mediating role of distress tolerance demonstrated a trend-level indirect effect. Findings suggest that individuals who allocate greater visual resources to emotionally salient information tend to exhibit greater challenges in tolerating distress. Distress tolerance may help to link emotional reactivity neurobiology to future depressive symptoms. Building distress tolerance through emotion regulation strategies may be an appropriate strategy for decreasing depressive symptoms.

Indexed as

DepressionEmotionsAdolescentBrainHumansMagnetic Resonance ImagingOccipital LobeYoung AdultAdolescenceAffective distressDepressive symptomsEmotional reactivityEmotion regulationfMRI

Identifiers

PMID37263126
PMCPMC10330591
OpenAlexW4377944067

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.