ArticleeLife2023
The RNA helicase DDX39B activates FOXP3 RNA splicing to control T regulatory cell fate.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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0cells of the map it votes in
18citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- MAP4K2 suppresses antitumor immunity in a pancreatic cancer model by promoting Treg differentiation.The Journal of clinical investigation · 2026Article
- SNRPD2-mediated regulation of DDX39B splicing promotes endometrial cancer progression by suppressing the activation of CTSC cryptic exons.Cell death & disease · 2026Article
- The Nodding syndrome cerebrospinal fluid proteome: a lens into neurodevelopmental failure consistent with environmentally triggeredFrontiers in molecular neuroscience · 2026Article
- Single-cell transcriptomic profiling of the whole colony of Botrylloides diegensis: insights into tissue specialization and blastogenesis.Development (Cambridge, England) · 2025Article
- Direct In-Bone Protein Digestion With Subsequent LC Separation and Trap Ion Mobility MS Detection of Released Peptides as an Effective Tool for the Proteomic Characterization of Bone Tissues.Journal of separation science · 2025Article
- Alternative Splicing in Tumorigenesis and Cancer Therapy.Biomolecules · 2025Review
- Chemoproteomic Approach for Identifying Nuclear Arsenite-Binding Proteins.Chemical research in toxicology · 2025Article
- Established and Emerging Roles of DEAD/H-Box Helicases in Regulating Infection and Immunity.Immunological reviews · 2025Review
- DDX RNA helicases: key players in cellular homeostasis and innate antiviral immunity.Journal of virology · 2024Review
- Parsing the roles of DExD-box proteins DDX39A and DDX39B in alternative RNA splicing.Nucleic acids research · 2024Article
- Inefficient recruitment of DDX39B impedes pre-spliceosome assembly onRNA (New York, N.Y.) · 2024Article
- Critical Cellular Functions and Mechanisms of Action of the RNA Helicase UAP56.Journal of molecular biology · 2024Review
- The splicing regulators RBM5 and RBM10 are subunits of the U2 snRNP engaged with intron branch sites on chromatin.Molecular cell · 2024Article
- The RNA helicase DDX39A binds a conserved structure in chikungunya virus RNA to control infection.Molecular cell · 2023Article
- Review
- Early Splicing Complexes and Human Disease.International journal of molecular sciences · 2023Review
- Article
- Metabolic regulation of forkhead box P3 alternative splicing isoforms and their impact on health and disease.Frontiers in immunology · 2023Review
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 2 countries.
Minato Hirano *Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, United States.
Gaddiel Galarza-Muñoz *Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, United States.
Chloe NagasawaDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, United States.
Geraldine SchottDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, United States.
Liuyang WangDepartment of Molecular Genetics and Microbiology, Duke University, Durham, United States.
Alejandro L AntoniaDepartment of Molecular Genetics and Microbiology, Duke University, Durham, United States.
Vaibhav JainDuke Molecular Physiology Institute, Duke University, Durham, United States.
Xiaoying YuDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, United States.
Steven G WidenDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, United States.ORCID 0000-0002-6512-363X
Farren B S BriggsDepartment of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, United States.
Simon G GregoryDepartment of Molecular Genetics and Microbiology, Duke University, Durham, United States.
Dennis C KoDepartment of Molecular Genetics and Microbiology, Duke University, Durham, United States.ORCID 0000-0002-0113-5981
William S FaggDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, United States.
Shelton BradrickInstitute of Human Infections and Immunity, University of Texas Medical Branch, Galveston, United States.ORCID 0000-0003-1566-9797
Mariano A Garcia-BlancoDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, United States.ORCID 0000-0001-8538-1997
The University of Texas Medical Branch at Galveston · USDuke University · USCase Western Reserve University · USNagasaki Medical Center · JPUniversity of Virginia · US
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2MResearch Project 3: Role of Posttranslational Protein Modifications in the Pathogenesis of Ebola Virus DiseaseP01AI150585 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BUKREYEV, ALEXANDER · 2021 to 2025
$11.3MMedical Scientist Training Program Training GrantT32GM145449 · NIGMS · DUKE UNIVERSITY · PI Christopher D Kontos · 2022 to 2026
$6.6MUTMB Clinical and Translational Science AwardKL2TR001441 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI AMEREDES, BILL T · 2015 to 2024
$4.0MConsequences and mechanism of aberrant splicing in African American prostate cancer disparitiesR01CA204806 · NCI · GEORGE WASHINGTON UNIVERSITY · PI GARCIA-BLANCO, MARIANO A., LEE, NORMAN H · 2017 to 2021
$1.8MAN ATLAS OF SHARED GENETIC ARCHITECTURE CONNECTING CELL BIOLOGY AND HUMAN DISEASER21AI133305 · NIAID · DUKE UNIVERSITY · PI KO, DENNIS CHUN-YONE, WANG, LIUYANG · 2018 to 2019
$440kRegulation of IL7R splicing by DDX39B and its role in Multiple SclerosisF32NS087899 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GALARZA MUNOZ, GADDIEL · 2014 to 2017
$170kNCATS NIH HHS KL2 TR001441NCI NIH HHS R01 CA204806NIAID NIH HHS P01 AI150585NIAID NIH HHS R21 AI133305NIGMS NIH HHS T32 GM007171NIGMS NIH HHS T32 GM145449NIH HHS P01 AI150585NINDS NIH HHS F32 NS087899
Abstract
Genes associated with increased susceptibility to multiple sclerosis (MS) have been identified, but their functions are incompletely understood. One of these genes codes for the RNA helicase DExD/H-Box Polypeptide 39B (DDX39B), which shows genetic and functional epistasis with interleukin-7 receptor-α gene (
Indexed as
Multiple SclerosisT-Lymphocytes, RegulatoryDEAD-box RNA HelicasesForkhead Transcription FactorsGene Expression RegulationHumansRNA SplicingDDX39B protein, humanDEAD-box RNA HelicasesForkhead Transcription FactorsFOXP3 protein, humanautoimmunitybiochemistrychemical biologyDDX39BFOXP3humanimmunologyinflammationmultiple sclerosisRNA helicaseRNA splicing
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.