ArticleSocial cognitive and affective neuroscience2023
The default mode network and rumination in individuals at risk for depression.
Article in Social cognitive and affective neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 4 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 4 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Neural systems underlying autobiographical memory dysregulations in depression: A neuroimaging meta-analysis.Psychological medicine · 2025Pooled it
- Nitrous oxide for the treatment of depression: a systematic review and meta-analysis.EBioMedicine · 2025Pooled it
- Catalyst for change: Psilocybin's antidepressant mechanisms-A systematic review.Journal of psychopharmacology (Oxford, England) · 2025Pooled it
- Brain connectivity changes underlying depression and fatigue in relapsing-remitting multiple sclerosis: A systematic review.PloS one · 2024Pooled it
- Bilateral intermittent theta burst stimulation over the primary motor cortex improves motor and affective symptoms via thalamic network reintegration in mid-stage Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Trial
- Towards causal inference-based antidepressant selection with brain and blood biomarkers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Subtyping depression using brain-gastric electrophysiology for early prediction of antidepressant response: a multicentric clinical study.Frontiers in psychiatry · 2026Trial
- The impact of an app-delivered mindfulness-based intervention on resting-state functional connectivity in pediatric concussion: a pilot study.Frontiers in neuroscience · 2026Trial
- Cognitive Specificity Enhancement Training (CoST) in depressed patients with a history of childhood maltreatment: a pilot study on the feasibility and efficacy of CoST for reducing rumination, cognitive avoidance, and depressive symptoms.European journal of psychotraumatology · 2025Trial
- Repetitive transcranial magnetic stimulation (rTMS) combined with antidepressant pharmacotherapy for depression: state-dependent mechanisms, clinical evidence, and translational challenges.Molecular psychiatry · 2026Review
- Characterizing gradients of functional connectome underpinning rumination and their alteration in depression.Translational psychiatry · 2026Article
- The dynamics of AMPA receptors underlies the efficacy of ketamine in treatment resistant patients with depression.Molecular psychiatry · 2026Article
- Neural correlates of acceptance and commitment therapy in major depressive disorder: a task-based fMRI study.Brain imaging and behavior · 2026Article
- Time to Address Eating Disorder Risk Among Medical Students.Behavioral sciences (Basel, Switzerland) · 2026Review
- Individualized Subcortical Functional Brain Organization Is Related to Diagnosis, Symptoms, and Behavior in Major Depressive Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Functional Breakdown of Temporoparietal Junction Interaction in High-depression Individuals: Evidence from Multi-Metric Connectomics.Brain structure & function · 2026Article
- Brain Changes Underlying Irritable Bowel Syndrome Symptom Improvement in Response to Mindfulness-Based Stress Reduction.Neurogastroenterology and motility · 2026Article
- Dynamic coactivation patterns during repetitive negative thinking: A cross-sectional fMRI study.Psychological medicine · 2026Article
- A Blueprint for Implementing Ketamine-Assisted Psychotherapy in Palliative Care: Design, Process, and Treatment Patterns of a Real-World Clinical Program.Journal of palliative medicine · 2026Article
- Neurophysiological features in women with antenatal depressive symptoms: a resting-state quantitative electroencephalography study.European archives of psychiatry and clinical neuroscience · 2026Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The default mode network (DMN) is a network of brain regions active during rest and self-referential thinking. Individuals with major depressive disorder (MDD) show increased or decreased DMN activity relative to controls. DMN activity has been linked to a tendency to ruminate in MDD. It is unclear if individuals who are at risk for, but who have no current or past history of depression, also show differential DMN activity associated with rumination. We investigated whether females with high levels of neuroticism with no current or lifetime mood or anxiety disorders (n = 25) show increased DMN activation, specifically when processing negative self-referential information, compared with females with average levels of neuroticism (n = 28). Participants heard criticism and praise during functional magnetic resonance imaging (MRI) scans in a 3T Siemens Prisma scanner. The at-risk group showed greater activation in two DMN regions, the medial prefrontal cortex and the inferior parietal lobule (IPL), after hearing criticism, but not praise (relative to females with average levels of neuroticism). Criticism-specific activation in the IPL was significantly correlated with rumination. Individuals at risk for depression may, therefore, have an underlying neurocognitive vulnerability to use a brain network typically involved in thinking about oneself to preferentially ruminate about negative, rather than positive, information.
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