ArticleJournal of the National Cancer Institute2023
Disparities in parental distress in a multicenter clinical trial for pediatric acute lymphoblastic leukemia.
Article in Journal of the National Cancer Institute, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 10 citations in OpenAlex.
- Providing Groceries and Transportation to Poverty-Exposed Pediatric Oncology Families: The PediCARE Pilot Randomized Clinical Trial.JAMA network open · 2024Trial
- Pediatric Oncology Clinical Trial Participation Among Families From Historically Marginalized Groups.JAMA network open · 2026Article
- Prevalence and Trajectory of Household Material Hardship Among Children With Advanced Cancer.Pediatric blood & cancer · 2026Article
- Food and Nutrition Insecurity in Cancer Survivorship: A Global Scoping Review.Cancer medicine · 2026Article
- Pediatric RISE: Development of a Poverty-Targeted Cash Support Intervention for Pediatric Cancer.Pediatric blood & cancer · 2026Article
- Caregivers' Perspectives on Changes in Family Life During B-ALL Therapy: A Qualitative Study From the Children's Oncology Group.Pediatric blood & cancer · 2025Article
- Parents' Experiences and Clinicians' Perceptions of Managing Cancer Pain in Young Children at Home.Current oncology (Toronto, Ont.) · 2025Article
- Targeting hardship: poverty as a modifiable risk factor in childhood leukemia and lymphoma treatment.Hematology. American Society of Hematology. Education Program · 2024Review
- Article
- Mental Health Care Utilization Among Parents of Children With Cancer.JAMA network open · 2024Article
- Financial burden and recommended multilevel solutions among caregivers of pediatric hematopoietic stem cell transplant recipients.Pediatric blood & cancer · 2023Article
Corrections and comments
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Authors and funding
16 authors at 10 institutions in 2 countries.
Funding
Abstract
backgroundParent psychological distress during childhood cancer treatment has short- and long-term implications for parent, child, and family well-being. Identifying targetable predictors of parental distress is essential to inform interventions. We investigated the association between household material hardship (HMH), a modifiable poverty-exposure defined as housing, food, or utility insecurity, and severe psychological distress among parents of children aged 1-17 years with acute lymphoblastic leukemia (ALL) enrolled on the multicenter Dana-Farber ALL Consortium Trial 16-001.
methodsThis was a secondary analysis of parent-reported data. Parents completed an HMH survey within 32 days of clinical trial enrollment (T0) and again at 6 months into therapy (T1). The primary exposure was HMH at T0 and primary outcome was severe parental distress at T0 and T1, defined as a score greater than or equal to 13 on the Kessler-6 Psychological Distress Scale. Multivariable models were adjusted for ALL risk group and single parent status.
resultsAmong 375 evaluable parents, one-third (32%; n = 120/375) reported HMH at T0. In multivariable analyses, T0 HMH was associated with over twice the odds of severe psychological distress at T0 and T1 HMH was associated with over 5 times the odds of severe distress at T1.
conclusionsDespite uniform clinical trial treatment of their children at well-resourced pediatric centers, HMH-exposed parents-compared with unexposed parents-experienced statistically significantly increased odds of severe psychological distress at the time of their child's leukemia diagnosis, which worsened 6 months into therapy. These data identify a high-risk parental population who may benefit from early psychosocial and HMH-targeted interventions to mitigate disparities in well-being.
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