Evidence map›Paper›PMID 37261730›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2023

Severe and fatal neonatal infections linked to a new variant of echovirus 11, France, July 2022 to April 2023.

Mathilde Grapin, Audrey Mirand, Didier Pinquier, Aurélie Basset, Matthieu Bendavid, Maxime Bisseux, Marion Jeannoël, Bérengère Kireche, Manoelle Kossorotoff, Anne-Sophie L'Honneur and 13 more

Abstract readComment
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. An RNA-to-RNA pipeline for rapid antiviral antibody development.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
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  20. Neonatal acute liver failure cases with echovirus 11 infections, Japan, August to November 2024.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Mathilde GrapinPaediatric Intensive Care Unit, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France.
Audrey MirandThese authors contributed equally to the work and share the first authorship.
Didier PinquierNeonatal and Paediatric Intensive Care Units, Rouen University Hospital, Rouen, France.
Aurélie BassetNeonatal Intensive Care Unit, Cochin-Port Royal University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France.
Matthieu BendavidPaediatric Intensive Care Unit, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France.
Maxime BisseuxClermont-Ferrand University Hospital, 3IHP - Infection Inflammation et Interaction Hôtes Pathogènes Virology Department, French Reference Centre for enteroviruses and parechovirus, coordination laboratory, Clermont-Ferrand, France.
Marion JeannoëlHospices Civils de Lyon, Virology Department, French Reference Centre for enteroviruses and parechoviruses, associated laboratory, Lyon, France.
Bérengère KirecheNeonatal and Paediatric Intensive Care Units, Orléans Regional Hospital, Orléans, France.
Manoelle KossorotoffPaediatric Neurology Department, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France.
Anne-Sophie L'HonneurVirology laboratory, Cochin University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France.
Lila RobinNeonatal and Paediatric Intensive Care Units, Orléans Regional Hospital, Orléans, France.
Yves VilleObstetrics and Fetal Medicine Department, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France.
Sylvain RenolleauPaediatric Intensive Care Unit, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France.
Véronique LemeeVirology Department, Rouen University Hospital, Rouen, France.
Pierre-Henri JarreauNeonatal Intensive Care Unit, Cochin-Port Royal University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France.
Isabelle DesguerrePaediatric Neurology Department, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France.
Florence LacaillePediatric Gastroenterology-Hepatology-Nutrition Unit, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, University of Paris, Paris, France.
Marianne Leruez-VilleClinical Microbiology laboratory and Virology unit, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France.
Clémence GuillaumeOrléans Hospital, Microbiology laboratory, Orléans, France.
Cécile HenquellClermont-Ferrand University Hospital, 3IHP - Infection Inflammation et Interaction Hôtes Pathogènes Virology Department, French Reference Centre for enteroviruses and parechovirus, coordination laboratory, Clermont-Ferrand, France.
Alexandre LapillonneNeonatal Intensive Care Unit, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France.
Isabelle SchuffeneckerThese authors contributed equally to the work and share the last authorship.
Mélodie AubartLaboratory of Human Genetics of Infectious Diseases, Necker Branch, Imagine Institute, Institut National de la Santé et de la Recherche Médicale U1163, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report nine severe neonatal infections caused by a new variant of echovirus 11. All were male, eight were twins. At illness onset, they were 3-5 days-old and had severe sepsis and liver failure. This new variant, detected in France since April 2022, is still circulating and has caused more fatal neonatal enterovirus infections in 2022 and 2023 (8/496; 1.6%, seven associated with echovirus 11) compared with 2016 to 2021 (7/1,774; 0.4%). National and international alerts are warranted.

Indexed as

Communicable DiseasesEchovirus InfectionsEnterovirusEnterovirus InfectionsEnterovirus B, HumanFemaleFranceHumansInfant, NewbornMaleEchovirus-11Enterovirusliver failureneonatal sepsis

Identifiers

PMID37261730
PMCPMC10236930

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.