Trial reportSchizophrenia bulletin2024
The Cost-Effectiveness of a Novel Online Social Therapy to Maintain Treatment Effects From First-Episode Psychosis Services: Results From the Horyzons Randomized Controlled Trial.
Trial report in Schizophrenia bulletin, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Moderated Online Social Therapy (MOST) in Help-Seeking Young People: Pilot Randomized Controlled Study.Journal of medical Internet research · 2025Trial
- Bipolar Early Intervention Using New Digital Technologies (BLEND): A Pilot Randomised Controlled Trial of a Novel Blended-Digital Early Intervention Model of Care for Youth With Bipolar Disorder I or II.Early intervention in psychiatry · 2025Trial
- Using smartphone-based assessment of social experience to predict relapse in first-episode psychosis.Schizophrenia (Heidelberg, Germany) · 2026Article
- Who Gets FIp? Understanding Contextual Factors in EIP Provision.Early intervention in psychiatry · 2026Article
- Bridging gaps in youth mental health care: YOUTHreach-a comprehensive European strategy.European child & adolescent psychiatry · 2026Article
- Towards a Multi-sectoral Approach to Population Health: A Scoping Review of Cross-sectoral Evaluations of Health Interventions.Applied health economics and health policy · 2026Review
- Sustained engagement with a digital youth mental health platform: A mixed-methods study.Internet interventions · 2026Article
- Article
- Insights from fifteen years of real-world development, testing and implementation of youth digital mental health interventions.Internet interventions · 2025Review
- User Character Strengths and Engagement Prediction on a Digital Mental Health Platform for Young People: Longitudinal Observational Study.Journal of medical Internet research · 2025Observational
- Acceptance and commitment therapy applied to early psychosis: Therapeutic foundations and a narrative systematic review.World journal of psychiatry · 2025Article
- A meta-analysis of persuasive design, engagement, and efficacy in 92 RCTs of mental health apps.NPJ digital medicine · 2025Article
- A national evaluation of a multi-modal, blended, digital intervention integrated within Australian youth mental health services.Acta psychiatrica Scandinavica · 2025Article
- Digital Interventions for the Rehabilitation of First-Episode Psychosis: An Integrated Perspective.Brain sciences · 2025Review
- Article
- SEMABehavior research methods · 2024Article
- A Novel Blended Transdiagnostic Intervention (eOrygen) for Youth Psychosis and Borderline Personality Disorder: Uncontrolled Single-Group Pilot Study.JMIR mental health · 2024Article
- The Effects of a Digital, Transdiagnostic, Clinically and Peer-Moderated Treatment Platform for Young People With Emerging Mental Health Complaints: Repeated Measures Within-Subjects Study.JMIR mHealth and uHealth · 2023Article
- Developing a Theory of Change for a Digital Youth Mental Health Service (Moderated Online Social Therapy): Mixed Methods Knowledge Synthesis Study.JMIR formative research · 2023Article
- Towards a youth mental health paradigm: a perspective and roadmap.Molecular psychiatry · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 7 institutions in 4 countries.
Funding
Abstract
backgroundDigital interventions have potential applications in promoting long-term recovery and improving outcomes in first-episode psychosis (FEP). This study aimed to evaluate the cost-effectiveness of Horyzons, a novel online social therapy to support young people aged 16-27 years following discharge from FEP services, compared with treatment as usual (TAU) from a healthcare sector and a societal perspective. STUDY
designA cost-effectiveness analysis (CEA), based on the change in social functioning, and a cost-utility analysis (CUA) using quality-adjusted life years were undertaken alongside a randomized controlled trial. Intervention costs were determined from study records; resources used by patients were collected from a resource-use questionnaire and administrative data. Mean costs and outcomes were compared at 18 months and incremental cost-effectiveness ratios were calculated. Uncertainty analysis using bootstrapping and sensitivity analyses was conducted. STUDY
resultsThe sample included 170 participants: Horyzons intervention group (n = 86) and TAU (n = 84). Total costs were significantly lower in the Horyzons group compared with TAU from both the healthcare sector (-AU$4789.59; P < .001) and the societal perspective (-AU$5131.14; P < .001). In the CEA, Horyzons was dominant, meaning it was less costly and resulted in better social functioning. In the CUA, the Horyzons intervention resulted in fewer costs but also yielded fewer QALYs. However, group differences in outcomes were not statistically significant. When young people engaged more with the platform, costs were shown to decrease and outcomes improved.
conclusionsThe Horyzons intervention offers a cost-effective approach for improving social functioning in young people with FEP after discharge from early intervention services.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.