Evidence map›Paper›PMID 37261425›Full record

ArticleIUCrJ2023

Crystal structures and kinetic studies of a laboratory evolved aldehyde reductase explain the dramatic shift of its new substrate specificity.

Shruthi Sridhar, Alberto Zavarise, Tiila Riikka Kiema, Subhadra Dalwani, Tor Eriksson, Yannick Hajee, Thilak Reddy Enugala, Rik K Wierenga, Mikael Widersten

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IUCrJ, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Shruthi SridharDepartment of Chemistry - BMC, Uppsala University, SE-751 23 Uppsala, Sweden.
Alberto ZavariseDepartment of Chemistry - BMC, Uppsala University, SE-751 23 Uppsala, Sweden.
Tiila Riikka KiemaBiocenter Oulu, University of Oulu, PO Box 5000, Oulu FI-90014, Finland.
Subhadra DalwaniFaculty of Biochemistry and Molecular Medicine, University of Oulu, PO Box 5400, Oulu FI-90014, Finland.
Tor ErikssonDepartment of Chemistry - BMC, Uppsala University, SE-751 23 Uppsala, Sweden.
Yannick HajeeDepartment of Chemistry - BMC, Uppsala University, SE-751 23 Uppsala, Sweden.
Thilak Reddy EnugalaDepartment of Chemistry - BMC, Uppsala University, SE-751 23 Uppsala, Sweden.
Rik K WierengaFaculty of Biochemistry and Molecular Medicine, University of Oulu, PO Box 5400, Oulu FI-90014, Finland.ORCID 0000-0001-6554-471X
Mikael WiderstenDepartment of Chemistry - BMC, Uppsala University, SE-751 23 Uppsala, Sweden.ORCID 0000-0002-3203-3793
Uppsala University · SEUniversity of Oulu · FI

Funding

Academy of Finland 339894Olle Engkvist Byggmästare Foundation 194-0638
6 · The paper itself

Abstract

The Fe

Indexed as

Aldehyde ReductaseEscherichia coliAcetaldehydeAldehydesCatalytic DomainKineticsSubstrate SpecificityAcetaldehydeAldehyde ReductaseAldehydeslactaldehydephenylacetaldehydealdehyde reductasedirected evolutionenzyme functionsenzyme mechanismsFucOsubstrate selectivity

Identifiers

PMID37261425
PMCPMC10324492
OpenAlexW4378953220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.