ReviewCureus2023
Adverse Events Reported From Hyaluronic Acid Dermal Filler Injections to the Facial Region: A Systematic Review and Meta-Analysis.
Review in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Combined and Hybrid Treatments of Hyaluronic Acid (HA) and Calcium Hydroxylapatite (CaHA): A Systematic Review of Mechanisms of Action, Aesthetic Effectiveness, Satisfaction, and Safety Profile.Aesthetic plastic surgery · 2025Pooled it
- Aesthetic lip filler augmentation is not free of adverse reactions: lack of evidence-based practice from a systematic review.Frontiers in oral health · 2024Pooled it
- Comparative Efficacy and Patient-centered Outcomes of Intraoral Submucosal Zonal Injection Versus Traditional Extra-oral Injection for Improving Perioral Contour: A Randomized Controlled Trial.Aesthetic plastic surgery · 2026Trial
- Twelve-Month Outcome of Nasolabial Fold Correction by a Novel Non-1,4-Butanediol Diglycidyl Ether, Click-Crosslinked, Long-Chain Hyaluronic Acid Product.Journal of cosmetic dermatology · 2026Trial
- Lip Augmentation With Saypha LIPS Lidocaine: A Postmarket, Prospective, Open-Label, Randomized Clinical Study To Evaluate Its Efficacy and Short- and Long-term Safety.Aesthetic surgery journal · 2024Trial
- Ocular Adipostructuring in Complications From Orbital Fillers: Managing the Orbital Base.Cureus · 2026Article
- Hypersensitivity Reactions to Injectable Fillers and Their Impact on Cosmetic Procedure Results.Aesthetic plastic surgery · 2026Observational
- Global Research Trends and Thematic Evolution in Injectable Aesthetic Medicine: A 25-year Bibliometric Analysis (2000-2025).Plastic and reconstructive surgery. Global open · 2026Article
- Clavicular augmentation with hyaluronic acid six-point technique: A novel non-surgical approach to skeletal definition.JPRAS open · 2026Article
- The Safety Profile of a Portfolio of Hyaluronic Acid-Based Soft Tissue Fillers Manufactured Using MACRO Technology: A Systematic Review of Clinical Evidence.Life (Basel, Switzerland) · 2026Review
- Hyaluronic Acid Filler CPM-V ± Lidocaine for Chin Augmentation: A Randomized, Multicenter, Open-Label Post-Market Follow-Up Study.Clinical, cosmetic and investigational dermatology · 2026Article
- An 18-Month Prospective Evaluation of a Novel Hyaluronic Acid Filler (YYS 720) for 3-Dimensional Nasal and Chin Augmentation.Aesthetic surgery journal. Open forum · 2026Article
- Prospective assessment on the cephalometric profile changes induced by labial hyaluronic acid infiltrations: A before-and-after study.Journal of clinical and experimental dentistry · 2026Review
- Facial Injectable Fillers in Aesthetic Medicine: Clinical Applications and Safety Strategies.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Evaluation of Hyaluronic Acid Filler Injections in Mice Over 28 Days: A Controlled In Vivo Study.Plastic and reconstructive surgery. Global open · 2025Article
- The Effect of Treatment With Hyaluronic Acid Dermal Fillers on Skin Changes and Quality of Life in Oncology Patients.Journal of cosmetic dermatology · 2025Article
- Comparison Combination of Autologous Fibroblast Cells Plus Platelet Rich Plasma (PRP) With PRP Alone in Treatment of Atrophic Acne Scars, a Split-Face Pilot Study With Biometric Assessment.Journal of cosmetic dermatology · 2025Article
- Article
- Comparing the Safety and Effectiveness of PCL and PLLA Injections for Nasolabial Fold Correction.Journal of cosmetic dermatology · 2025Article
- Role of Hyaluronic Acid in Post-Blepharoplasty Volume Restoration and Complication Management: A Systematic Review.Journal of clinical medicine · 2025Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dermal filler injections are one of the most popular cosmetic procedures in the United States. Of the many options available, hyaluronic acid (HA) dermal fillers like Juvederm or Restylane are often used. Despite their use and popularity, adverse events are known to occur from these procedures. Although most outcomes may be mild and resolve over time, rare instances of severe complications cannot be ignored, as these effects may be irreversible. Healthcare practitioners and patients must be aware of these risks, as these cosmetic procedures can affect the patient's quality of life. The aim of this study was to evaluate the incidence of adverse events (AEs) reported from the use of hyaluronic acid dermal fillers in the facial region. A systemized search of randomized controlled trials was conducted using Cochrane Central, Embase, Medical Literature Analysis and Retrieval System Online (MEDLINE), and the Web of Science databases. After screening for eligibility and conducting a critical appraisal of the articles, 19 studies were retained for the final review. The meta-analysis results included different side effects by facial location, i.e., nasolabial fold
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.