Evidence map›Paper›PMID 37261036›Full record

ArticleJournal of oral microbiology2023

Newly identified pathogens in periodontitis: evidence from an association and an elimination study.

Eduardo Lobão Veras, Nídia Castro Dos Santos, João Gabriel S Souza, Luciene C Figueiredo, Belen Retamal-Valdes, Valentim A R Barão, Jamil Shibli, Martinna Bertolini, Marcelo Faveri, Flavia Teles and 2 more

Abstract read
In one paragraph

Article in Journal of oral microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Trial
  2. Article
  3. Effects of Non-Surgical Periodontal Therapy on Dental Plaque Microbiome.International journal of molecular sciences · 2026
    Article
  4. Effects of Non-Surgical Periodontal Therapy on Dental Plaque Microbiome.medRxiv : the preprint server for health sciences · 2026
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Obtaining Muramic Acid fromLife (Basel, Switzerland) · 2025
    Article
  13. Article
  14. International journal of molecular sciences · 2025
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Eduardo Lobão VerasDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, SP, Brazil.
Nídia Castro Dos SantosDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, SP, Brazil.
João Gabriel S SouzaDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, SP, Brazil.
Luciene C FigueiredoDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, SP, Brazil.
Belen Retamal-ValdesDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, SP, Brazil.
Valentim A R BarãoDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, Brazil.
Jamil ShibliDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, SP, Brazil.
Martinna BertoliniDepartment of Periodontics and Preventive Dentistry, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Marcelo FaveriDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, SP, Brazil.
Flavia TelesCenter for Innovation & Precision Dentistry, School of Dental Medicine, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA.
Poliana DuarteDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, SP, Brazil.
Magda FeresDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, SP, Brazil.ORCID https://orcid.org/0000-0002-2293-3392

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We assessed the level of evidence for the presence of new periodontal pathogens by (i) comparing the occurrence of non-classical periodontal taxa between healthy vs. periodontitis patients (Association study); (ii) assessing the modifications in the prevalence and levels of these species after treatments (Elimination study). In the Association study, we compared the prevalence and levels of 39 novel bacterial species between periodontally healthy and periodontitis patients. In the Elimination study, we analyzed samples from periodontitis patients assigned to receive scaling and root planing alone or with metronidazole+ amoxicillin TID/ 14 days. Levels of 79 bacterial species (39 novel and 40 classic) were assessed at baseline, 3 and 12 months post-therapy. All samples were analyzed using Checkerboard DNA-DNA hybridization. Out of the 39 novel species evaluated, eight were categorized as having strong and four as having moderate association with periodontitis. Our findings suggest strong evidence supporting

Indexed as

etiologyMicrobiotanew pathogensoral microbiologyperiodontal treatmentPeriodontitis

Identifiers

PMID37261036
PMCPMC10228317

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.