Evidence map›Paper›PMID 37260580›Full record

ArticleFrontiers in cellular neuroscience2023

PLC regulates spontaneous glutamate release triggered by extracellular calcium and readily releasable pool size in neocortical neurons.

Maya G Feldthouse, Nicholas P Vyleta, Stephen M Smith

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Frequency of Spontaneous Neurotransmission at Individual Boutons Corresponds to the Size of the Readily Releasable Pool of Vesicles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Maya G Feldthouse *Section of Pulmonary and Critical Care Medicine and Research and Development, VA Portland Health Care System, Portland, OR, United States.
Nicholas P Vyleta *Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, OR, United States.
Stephen M SmithSection of Pulmonary and Critical Care Medicine and Research and Development, VA Portland Health Care System, Portland, OR, United States.
Oregon Health & Science University · USVA Portland Health Care System · US

Funding

Sodium channel control of neuronal excitabilityR01GM134110 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI SMITH, STEPHEN M · 2020 to 2022
$652k
BLRD VA I01 BX002547NIGMS NIH HHS R01 GM134110
6 · The paper itself

Abstract

Introduction: Dynamic physiological changes in brain extracellular calcium ([Ca Methods: Patch-clamping cultured neocortical neurons, we tested how spontaneous glutamate release was affected by [Ca Results: Spontaneous glutamate release substantially increased with [Ca Discussion: Together these data point to a strong role for PLC in mediating changes in spontaneous release elicited by [Ca

Indexed as

calcium-sensing receptorextracellular calciumGPCRminisPLCreadily releasable poolspontaneous release

Identifiers

PMID37260580
PMCPMC10228687
OpenAlexW4376955000

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.