ArticleInternational journal of reproductive biomedicine2023
Negative effect of varicocele on sperm mitochondrial dysfunction: A cross-sectional study.
Article in International journal of reproductive biomedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- The role of gene polymorphisms in infertility, polyendocrine metabolic ovarian syndrome and recurrent miscarriage in the Iranian women population: A review study.International journal of reproductive biomedicine · 2026Review
- Article
- A narrative review of mitochondrial dysfunction and male infertility.Translational andrology and urology · 2024Review
- Comments on "Negative effect of varicocele on sperm mitochondrial dysfunction: A cross-sectional study".International journal of reproductive biomedicine · 2024Article
- Robotic-assisted versus conventional laparoscopic ICG-fluorescence lymphatic-sparing palomo varicocelectomy: a comparative retrospective study of techniques and outcomes.World journal of urology · 2024Article
- Review
- Assessment of Seminal Lactoferrin Levels in Oligoasthenoterato-zoospermic Men with Varicocele.Journal of reproduction & infertilityArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Varicocele is an abnormal dilation and enlargement of the scrotal venous pampiniform plexus that impairs normal blood drainage and finally leads to infertility if not treated. Objective: This study aimed to figure out the impact of mitochondria status through the mitochondrial membrane potential (MMP) and adenosine triphosphate (ATP) assessment and its correlation with semen parameters to illuminate the impact of sperm mitochondria healthiness on normal sperm functionality. Materials and Methods: This analytical cross-sectional study was conducted with 100 men including 50 cases in the normozoospermic group (normal) and 50 in an infertile group with the non-varicocelectomy operation (varicocele) referring to Infertility Research and Treatment Center, ACECR Khuzestan, Iran. Routine semen analysis was performed according to World Health Organization guidelines, DNA fragmentation index, the MMP assay, ATP content, and apoptosis were carried out for all samples. Results: The results showed that the concentration, progressive motility, normal morphology, MMP, and ATP contents of sperm in varicocele were significantly lower than the normal group. In addition, the sperm DNA fragmentation index was significantly higher in the varicocele group in comparison with the normal group. Conclusion: Reduction in MMP and ATP contents, besides the loss of sperm parameters quality and increase in sperm DNA fragmentation, were seriously implicating sperm mitochondria dysfunctionality in varicocele men.
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Registered trials
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