ArticleNanoscale advances2023
Exosomes trapping, manipulation and size-based separation using opto-thermo-electrohydrodynamic tweezers.
Article in Nanoscale advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Extracellular vesicle-mediated gene editing for the treatment of nonsyndromic progressive hearing loss in adult mice.Science translational medicine · 2025Article
- Microfluidic devices for on-chip quantification of extracellular vesicles and associated biomarkers.Extracellular vesicles and circulating nucleic acids · 2025Review
- Rapid and Sensitive Detection by Combining Electric Field Effects and Surface Plasmon Resonance: A Theoretical Study.Micromachines · 2024Article
- Extracellular Vesicles and Exosomes: Novel Insights and Perspectives on Lung Cancer from Early Detection to Targeted Treatment.Biomedicines · 2024Review
- Recent Advancements in Nanophotonics for Optofluidics.Advances in physics: X · 2024Article
- Mirror-Enhanced Plasmonic Nanoaperture for Ultrahigh Optical Force Generation with Minimal Heat Generation.Nano letters · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Owing to the heterogeneity of exosomes in size and biomolecular composition, there is a need for new approaches for trapping, manipulating, and sorting of single exosomes in solution. Due to their small size ranging from 30 nm to 150 nm and their relatively low refractive index, their stable trapping using optical tweezers has been met with challenges. Trapping exosomes in an optical trap requires nearly 100 mW of input power, which predisposes them to photo-induced damage and membrane rupture at the laser focus. Here, we report a high stability opto-thermo-electrohydrodynamic tweezer for the stable stand-off trapping of single exosomes based on a concentric nanohole array (CNA) using laser illumination and an a.c. field. The CNA system generates two regions of electrohydrodynamic potentials several microns away from the laser focus where single exosomes are trapped. We demonstrate the rapid trapping within seconds, and selective dynamic manipulation of exosomes based on size using only 4.2 mW of input laser power. The proposed platform opens up a promising approach for stabilizing single exosomes in solution and controlling their distribution based on size without the risk of photo-induced damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.