Evidence map›Paper›PMID 37260495›Full record

ArticleNanoscale advances2023

A modular RNA delivery system comprising spherical nucleic acids built on endosome-escaping polymeric nanoparticles.

Antonio Garcia-Guerra, Ruth Ellerington, Jens Gaitzsch, Jonathan Bath, Mahnseok Kye, Miguel A Varela, Giuseppe Battaglia, Matthew J A Wood, Raquel Manzano, Carlo Rinaldi and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanoscale advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Trojan Horses: A Secret Route for Nanomedicines.Current pharmaceutical biotechnology · 2025
    Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Antonio Garcia-GuerraDepartment of Physics, Clarendon Laboratory, University of Oxford Parks Road Oxford OX1 3PU UK.ORCID https://orcid.org/0000-0003-1350-3558
Ruth ElleringtonDepartment of Paediatrics, University of Oxford Le Gros Clark Building, South Parks Road Oxford OX1 3QX UK.ORCID https://orcid.org/0000-0001-7978-9873
Jens GaitzschDepartment of Chemistry, University College London London WC1H 0AJ UK.ORCID https://orcid.org/0000-0002-8858-982X
Jonathan BathDepartment of Physics, Clarendon Laboratory, University of Oxford Parks Road Oxford OX1 3PU UK.ORCID https://orcid.org/0000-0002-7144-662X
Mahnseok KyeDepartment of Paediatrics, University of Oxford Le Gros Clark Building, South Parks Road Oxford OX1 3QX UK.ORCID https://orcid.org/0000-0001-7809-4949
Miguel A VarelaDepartment of Paediatrics, University of Oxford Le Gros Clark Building, South Parks Road Oxford OX1 3QX UK.ORCID https://orcid.org/0000-0003-4376-9381
Giuseppe BattagliaDepartment of Chemistry, University College London London WC1H 0AJ UK.ORCID https://orcid.org/0000-0003-3349-6770
Matthew J A WoodDepartment of Paediatrics, University of Oxford Le Gros Clark Building, South Parks Road Oxford OX1 3QX UK.ORCID https://orcid.org/0000-0002-5436-6011
Raquel ManzanoDepartment of Paediatrics, University of Oxford Le Gros Clark Building, South Parks Road Oxford OX1 3QX UK.ORCID https://orcid.org/0000-0002-7477-8742
Carlo RinaldiDepartment of Paediatrics, University of Oxford Le Gros Clark Building, South Parks Road Oxford OX1 3QX UK.ORCID https://orcid.org/0000-0002-8307-6638
Andrew J TurberfieldDepartment of Physics, Clarendon Laboratory, University of Oxford Parks Road Oxford OX1 3PU UK.ORCID https://orcid.org/0000-0002-3876-0190
University of Oxford · GBInstitució Catalana de Recerca i Estudis Avançats · ESLeibniz Institute of Polymer Research · DEUniversidad de Zaragoza · ES

Funding

Medical Research Council MC_PC_16056Wellcome Trust 205162/Z/16/Z
6 · The paper itself

Abstract

Nucleic acid therapeutics require delivery systems to reach their targets. Key challenges to be overcome include avoidance of accumulation in cells of the mononuclear phagocyte system and escape from the endosomal pathway. Spherical nucleic acids (SNAs), in which a gold nanoparticle supports a corona of oligonucleotides, are promising carriers for nucleic acids with valuable properties including nuclease resistance, sequence-specific loading and control of receptor-mediated endocytosis. However, SNAs accumulate in the endosomal pathway and are thus vulnerable to lysosomal degradation or recycling exocytosis. Here, an alternative SNA core based on diblock copolymer PMPC

Identifiers

PMID37260495
PMCPMC10228346
OpenAlexW4378952057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.