Evidence map›Paper›PMID 37260461›Full record

ArticleERJ open research2023

Asthma innovations from the first International Collaborative Asthma Network forum.

Benjamin Gaston, Donna D Gardner, Kenzie Mahan, Praveen Akuthota, Eneida A Mendonca, Hannah Durrington, Nadzeya Marozkina, Rocio T Martinez-Nunez, Dawn Newcomb, Benjamin Ainsworth and 11 more

Open access · goldAbstract read
In one paragraph

Article in ERJ open research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Asthma innovations from the second International Collaborative Asthma Network (ICAN) forum.The Journal of asthma : official journal of the Association for the Care of Asthma · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 13 institutions in 2 countries.

Benjamin GastonIndiana University, Indianapolis, IN, USA.
Donna D GardnerAllergy and Asthma Network, Fairfax, VA, USA.ORCID https://orcid.org/0000-0001-5541-7397
Kenzie MahanIndiana University, Indianapolis, IN, USA.
Praveen AkuthotaUniversity of California San Diego, La Jolla, CA, USA.
Eneida A MendoncaIndiana University, Indianapolis, IN, USA.
Hannah DurringtonDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID https://orcid.org/0000-0002-9990-9446
Nadzeya MarozkinaIndiana University, Indianapolis, IN, USA.
Rocio T Martinez-NunezKing's College London, London, UK.
Dawn NewcombVanderbilt University Medical Center, Nashville, TN, USA.
Benjamin AinsworthUniversity of Southampton, Southampton, UK.ORCID https://orcid.org/0000-0002-5098-1092
Arthur H OworaIndiana University, Indianapolis, IN, USA.
Kian Fan ChungNational Heart and Lung Institute, Imperial College London, London, UK.
Samantha WalkerAsthma and Lung UK, London, UK.
Stephen J FowlerDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID https://orcid.org/0000-0002-4524-1663
Salman SiddiquiNational Heart and Lung Institute, Imperial College London, London, UK.
Tonya WindersAllergy and Asthma Network, Fairfax, VA, USA.
Joe ZeinCleveland Clinic, Cleveland, OH, USA.
Nizar JarjourUniversity of Wisconsin, Madison, WI, USA.
Yvonne J HuangUniversity of Michigan, Ann Arbor, MI, USA.
Katherine N CahillVanderbilt University Medical Center, Nashville, TN, USA.ORCID https://orcid.org/0000-0002-8549-1835
Ratko DjukanovicUniversity of Southampton, Southampton, UK.
Indiana University – Purdue University Indianapolis · USAsthma and Allergy Foundation of America · USImperial College London · GBUniversity of Manchester · GBUniversity of Southampton · GBVanderbilt University Medical Center · USAsthma UK · GBCincinnati Children's Hospital Medical Center · USCleveland Clinic · USKing's College London · GBUniversity of California San Diego · USUniversity of Michigan · USUniversity of Wisconsin–Madison · US

Funding

S-nitrosylation signaling in asthmaP01HL158507 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI LAHM, TIM · 2021 to 2025
$12.0M
Sputum Microbial Markers of Type 2-Low AsthmaR01AI129958 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUANG, YVONNE JEAN · 2017 to 2021
$3.6M
Gender-based precision care for asthmaK08HL133381 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ZEIN, JOE · 2017 to 2021
$836k
Developing a Childhood Asthma Risk Passive Digital MarkerK01HL166436 · NHLBI · TRUSTEES OF INDIANA UNIVERSITY · PI OWORA, ARTHUR HAMIE · 2023 to 2024
$324k
Effect of iron status trajectories on lung function and asthma riskR03HS029088 · AHRQ · TRUSTEES OF INDIANA UNIVERSITY · PI OWORA, ARTHUR HAMIE · 2022 to 2024
$110k
AHRQ HHS R03 HS029088Medical Research Council MR/V029460/1NHLBI NIH HHS K01 HL166436NHLBI NIH HHS K08 HL133381NHLBI NIH HHS P01 HL158507NIAID NIH HHS R01 AI129958
6 · The paper itself

Abstract

Background: Many patients have uncontrolled asthma despite available treatments. Most of the new asthma therapies have focused on type 2 (T2) inflammation, leaving an unmet need for innovative research into mechanisms of asthma beyond T2 and immunity. An international group of investigators developed the International Collaborative Asthma Network (ICAN) with the goal of sharing innovative research on disease mechanisms, developing new technologies and therapies, organising pilot studies and engaging early-stage career investigators from across the world. This report describes the purpose, development and outcomes of the first ICAN forum. Methods: Abstracts were solicited from interdisciplinary early-stage career investigators with innovative ideas beyond T2 inflammation for asthma and were selected for presentation at the forum. Breakout sessions were conducted to discuss innovation, collaboration and research translation. Results: The abstracts were categorised into: 1) general omics and big data analysis; 2) lung-brain axis and airway neurology; 3) sex differences; 4) paediatric asthma; 5) new therapeutic targets inspired by airway epithelial biology; 6) new therapeutics targeting airway and circulating immune mediators; and 7) lung anatomy, physiology and imaging. Discussions revealed that research groups are looking for opportunities to further their findings using larger scale collaboration and the ability to translate their Conclusions: Through ICAN, teams that included interdisciplinary early-stage career investigators discussed innovation, collaboration and translation in asthma and severe asthma research. With a combination of fresh ideas and energetic, collaborative, global participation, ICAN has laid a firm foundation and model for future collaborative global asthma research.

Identifiers

PMID37260461
PMCPMC10227632
OpenAlexW4378212636

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.