ArticleFrontiers in endocrinology2023
Distinct serum steroid profiles between adrenal Cushing syndrome and Cushing disease.
Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 10 citations in OpenAlex.
- Beyond cortisol: multiplex steroid profiling after overnight dexamethasone suppression to optimize Cushing's syndrome screening.Endocrine · 2025Article
- Clinical, hormonal and radiological features, and treatment outcomes of prolactinomas in a pediatric population.Northern clinics of Istanbul · 2025Article
- No requirement of perioperative glucocorticoid replacement in patients with endogenous Cushing's syndrome - a pilot study.Endocrine · 2024Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
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Abstract
Background: Differentiating between adrenal Cushing syndrome (adrenal CS) and Cushing disease (CD) can be challenging if there are equivocal or falsely elevated adrenocorticotropic hormone (ACTH) values. We aim to investigate the diagnostic value of serum steroid profiles in differentiating adrenal CS from CD. Method: A total of 11 serum steroids in adrenal CS ( Results: The PCA and OPLS-DA analyses showed distinct serum steroid profiles between adrenal CS and CD. Dehydroepiandrosterone sulfate (DHEA-S), dehydroepiandrosterone (DHEA), and androstenedione ratios were identified as biomarkers for discrimination by variable importance in projection (VIP) in combination with Conclusion: Our data support the clinical use of the DHEA-S and DHEA ratios in the differential diagnosis of adrenal CS and CD, especially when falsely elevated ACTH is suspected.
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