ArticleTurkish journal of obstetrics and gynecology2023
How autologous platelet-rich plasma affects pregnancy and birth outcomes in women with repeated embryo implantation failure: A prisma-compliant meta-analysis.
Article in Turkish journal of obstetrics and gynecology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 5 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- The Value of Platelet-Rich Plasma Treatment in Reproductive Disorders: An Umbrella Review.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Pooled it
- Role of platelet-rich plasma in unexplained recurrent implantation failure: an umbrella review.Frontiers in reproductive health · 2026Pooled it
- Uterine infusion strategies for infertile patients with recurrent implantation failure: a systematic review and network meta-analysis.Reproductive biology and endocrinology : RB&E · 2024Pooled it
- Characteristics of sudden hearing loss after different COVID-19 vaccinations: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Pooled it
- Platelet rich plasma for assisted reproduction: an overview of systematic reviews.Blood transfusion = Trasfusione del sanguePooled it
- Platelet-Rich Plasma in Recurrent Pregnancy Loss: Toward a Precision Medicine Framework for Biologically Guided Patient Selection.Medical sciences (Basel, Switzerland) · 2026Review
- Optimizing the Endometrial Factor in Recurrent Implantation Failure: From Established Diagnostics to Mechanism-Informed Management.Journal of clinical medicine · 2026Review
- Effects of autologous platelet-rich plasma intrauterine perfusion on clinical outcomes in recurrent implantation failure patients with non-thin endometrium undergoing frozen-thawed embryo transfer.Archives of gynecology and obstetrics · 2025Article
- Study Protocol: Evaluating the Effect of Autologous Platelet-Rich Plasma Infusion in the Endometrial Cavity for Enhanced Embryo-Endometrium Synchrony in Patients with Repeated Implantation Failure.Journal of pharmacy & bioallied sciences · 2025Article
- Is it justified to offer intrauterine infusion of autologous PRP in women with repeated implantation failure?Human reproduction (Oxford, England) · 2025Review
- Article
- How Intravesical Platelet-Rich Plasma Can Help Patients with Interstitial Cystitis/Bladder Pain Syndrome: A Comprehensive Scoping Review.International urogynecology journal · 2024Article
- Article
- Hysteroscopic tubal electrocoagulation versus laparoscopic tubal disconnection for the management of hydrosalpinx and subsequent pregnancy outcomes: A randomized clinical trial.Turkish journal of obstetrics and gynecology · 2024Article
- Review
- Impact of Intrauterine Infusion of Autologous Platelet-Rich Plasma on Assisted Reproductive Outcomes in Patients With Recurrent Implantation Failure: A Meta-Analysis of Randomized Controlled Trials.Reproductive medicine and biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Repeated implantation failure refer to failure to conceive after three or more embryo transfer attempts. Several interventions were offered to improve maternal and fetal outcomes. Our objective was to investigate the impact of platelet-rich plasma (PRP) as a promising intervention to improve both pregnancy and birth outcomes. We searched PubMed, Scopus, Web of Science, and Cochrane Central, in addition to other relevant resources of grey literature. Only clinical trials were eligible to be included. We performed the meta-analysis using a random effects model. Eight randomized clinical trials, enrolling 1038 women with more than 3 implantation failure attempts, were included. We found a significant increase regarding all our prespecified primary outcomes. Chemical pregnancy rate [relative ratio (RR): 1.96, 95% confidence interval (CI): 1.61, 2.39; p<0.001], clinical pregnancy rate (RR: 4.35, 95% CI: 1.92, 2.88; p<0.001), and live birth rate (RR: 4.03, 95% CI: 1.29, 12.63; p=0.02) were found to be statistically significant and increased in patients who received PRP compared with the control group. Implantation rate (RR: 1.98, 95% CI: 1.34, 2.75; p<0.001), miscarriage rate (RR: 0.44, 95% CI: 0.23, 0.83, p=0.01), and multiple pregnancy rate (RR: 2.56, 95% CI: 1.02, 6.42, p=0.04) were also found to be significantly increased in the PRP group. We provide strong evidence on how intrauterine PRP can improve implantation, pregnancy, and birth outcomes in RIF women, which should direct clinicians to consider this intervention as a very effective tool in assisted reproductive techniques.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.