ArticleJournal of the American Heart Association2023
Congenitally Corrected Transposition of the Great Arteries: Fetal Diagnosis, Associations, and Postnatal Outcome: A Fetal Heart Society Research Collaborative Study.
Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Advancements in echocardiography for congenital heart defects (CHDs): a literature review.Annals of medicine and surgery (2012) · 2026Review
- Ablation of idiopathic fascicular ventricular tachycardia in a patient with congenitally corrected transposition of the great arteries: A case report.HeartRhythm case reports · 2026Article
- Ambulatory Fetal Heart Rate and Rhythm Monitoring for Pregnancies at Risk for Fetal Arrhythmias: Perspectives from the Fetal Heart Society.Pediatric cardiology · 2026Review
- Prenatally vs. Postnatally Diagnosed Congenitally Corrected Transposition of the Great Arteries is Associated with Higher Rates of Conduction Disease, Intervention and Earlier Mortality.Pediatric cardiology · 2026Article
- Prenatal Diagnosis of Isolated Congenitally Corrected Transposition of the Great Arteries.Cureus · 2026Article
- Reduced Ejection Fraction of the Systemic Right Ventricle and Severe Tricuspid Regurgitation: Medication or Surgery?Journal of cardiovascular development and disease · 2025Article
- Update on Surgery for Complex Transposition of the Great Arteries: Focusing on Aortic Root Translocation.Korean circulation journal · 2025Review
- Electrocardiographic and imaging findings in adult patients with congenitally corrected transposition of the great arteries: Case series.HeartRhythm case reports · 2025Article
- Review
- Congenitally Corrected Transposition of the Great Arteries in Utero: Morphological Spectrum, Outcomes and Pitfalls in Fetal Diagnosis.Pediatric cardiology · 2024Article
- From Other Journals: A Review of Recent Articles by Our Editorial Team.Pediatric cardiology · 2023Article
Corrections and comments
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Authors and funding
22 authors at 20 institutions in 3 countries.
Funding
Abstract
Background Fetal diagnosis of congenitally corrected transposition of the great arteries (ccTGA) has been increasingly reported; however, predictors of clinical outcomes remain underexplored. We undertook a multicenter, retrospective study to investigate natural history, associated anomalies, and outcomes of fetal ccTGA. Methods and Results Fetuses with ccTGA diagnosed from January 2004 to July 2020 within 20 North American programs were included. Fetuses with severe ventricular hypoplasia thought to definitively preclude biventricular repair were excluded. We included 205 fetuses diagnosed with ccTGA at a median gestational age of 23 (interquartile range, 21-27) weeks. Genetic abnormalities were found in 5.9% tested, with extracardiac anomalies in 6.3%. Associated cardiac defects were diagnosed in 161 (78.5%), with atrioventricular block in 23 (11.3%). On serial fetal echocardiogram, 39% demonstrated a functional or anatomic change, most commonly increased tricuspid regurgitation (6.7%) or pulmonary outflow obstruction (11.1%). Of 194 fetuses with follow-up, 26 were terminated, 3 experienced fetal death (2 with atrioventricular block), and 165 were live-born. Of 158 with postnatal data (median follow-up 3.7 years), 10 (6.6%) had death/transplant before 1 year. On univariable analysis, fetal factors associated with fetal death or death/transplant by 1 year included ≥ mild tricuspid regurgitation, pulmonary atresia, aortic obstruction, fetal arrhythmia, and worsening hemodynamics on serial fetal echocardiogram (defined as worse right ventricular function, tricuspid regurgitation, or effusion). Conclusions Associated cardiac lesions and arrhythmias are common in fetal ccTGA, and functional changes commonly occur through gestation. Worse outcomes are associated with fetal tricuspid regurgitation (≥mild), any arrhythmia, pulmonary atresia, aortic obstruction, and worsening hemodynamics on serial echocardiograms. These findings can inform prenatal counseling and perinatal management planning.
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