Evidence map›Paper›PMID 37259909›Full record

ArticleAutism research : official journal of the International Society for Autism Research2023

Relationship between quantitative digital behavioral features and clinical profiles in young autistic children.

Marika Coffman, J Matias Di Martino, Rachel Aiello, Kimberly L H Carpenter, Zhuoqing Chang, Scott Compton, Brian Eichner, Steve Espinosa, Jacqueline Flowers, Lauren Franz and 4 more

Abstract read
In one paragraph

Article in Autism research : official journal of the International Society for Autism Research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Autism Digital Phenotyping in Preschool- and School-Age Children.Autism research : official journal of the International Society for Autism Research · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Marika CoffmanDuke Center for Autism and Brain Development, Duke University, Durham, North Carolina, USA.ORCID 0000-0002-6715-7016
J Matias Di MartinoDepartment of Electrical and Computer Engineering, Duke University, Durham, North Carolina, USA.ORCID 0000-0002-4679-8666
Rachel AielloDuke Center for Autism and Brain Development, Duke University, Durham, North Carolina, USA.ORCID 0000-0002-5739-6304
Kimberly L H CarpenterDuke Center for Autism and Brain Development, Duke University, Durham, North Carolina, USA.ORCID 0000-0002-3838-798X
Zhuoqing ChangDepartment of Electrical and Computer Engineering, Duke University, Durham, North Carolina, USA.
Scott ComptonDuke Center for Autism and Brain Development, Duke University, Durham, North Carolina, USA.
Brian EichnerDepartment of Pediatrics, Duke University, Durham, North Carolina, USA.ORCID 0000-0002-4509-1060
Steve EspinosaOffice of Information Technology, Duke University, Durham, North Carolina, USA.
Jacqueline FlowersDuke Center for Autism and Brain Development, Duke University, Durham, North Carolina, USA.
Lauren FranzDuke Center for Autism and Brain Development, Duke University, Durham, North Carolina, USA.ORCID 0000-0003-4434-7500
Sam PerochonDepartment of Electrical and Computer Engineering, Duke University, Durham, North Carolina, USA.ORCID 0000-0002-1759-4154
Pradeep Raj Krishnappa BabuDepartment of Electrical and Computer Engineering, Duke University, Durham, North Carolina, USA.ORCID 0000-0001-8404-3320
Guillermo SapiroDepartment of Electrical and Computer Engineering, Duke University, Durham, North Carolina, USA.ORCID 0000-0001-9190-6964
Geraldine DawsonDuke Center for Autism and Brain Development, Duke University, Durham, North Carolina, USA.ORCID 0000-0003-1410-2764

Funding

Recruitment and Assessment CoreP50HD093074 · NICHD · DUKE UNIVERSITY · PI Geraldine Dawson, Lauren Franz · 2017 to 2026
$27.6M
Novel Approaches to Infant Screening for ASD in Pediatric Primary CareR01MH121329 · NIMH · DUKE UNIVERSITY · PI DAWSON, GERALDINE · 2019 to 2023
$3.9M
Scalable Computational Platform For Active Closed-Loop Behavioral Coding in Autism Spectrum DisorderR01MH120093 · NIMH · DUKE UNIVERSITY · PI DAWSON, GERALDINE, SAPIRO, GUILLERMO R · 2019 to 2022
$1.6M
NICHD NIH HHS P50 HD093074NIMH NIH HHS R01 MH120093NIMH NIH HHS R01MH120093NIMH NIH HHS R01 MH121329NIMH NIH HHS R01MH121329
6 · The paper itself

Abstract

Early behavioral markers for autism include differences in social attention and orienting in response to one's name when called, and differences in body movements and motor abilities. More efficient, scalable, objective, and reliable measures of these behaviors could improve early screening for autism. This study evaluated whether objective and quantitative measures of autism-related behaviors elicited from an app (SenseToKnow) administered on a smartphone or tablet and measured via computer vision analysis (CVA) are correlated with standardized caregiver-report and clinician administered measures of autism-related behaviors and cognitive, language, and motor abilities. This is an essential step in establishing the concurrent validity of a digital phenotyping approach. In a sample of 485 toddlers, 43 of whom were diagnosed with autism, we found that CVA-based gaze variables related to social attention were associated with the level of autism-related behaviors. Two language-related behaviors measured via the app, attention to people during a conversation and responding to one's name being called, were associated with children's language skills. Finally, performance during a bubble popping game was associated with fine motor skills. These findings provide initial support for the concurrent validity of the SenseToKnow app and its potential utility in identifying clinical profiles associated with autism. Future research is needed to determine whether the app can be used as an autism screening tool, can reliably stratify autism-related behaviors, and measure changes in autism-related behaviors over time.

Indexed as

Autism Spectrum DisorderAutistic DisorderCognitionHumansautismcomputer visiondigital phenotypingscreening

Identifiers

PMID37259909
PMCPMC10524806

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.