Evidence map›Paper›PMID 37259605›Full record

ArticleThe Journal of clinical endocrinology and metabolism2023

Glycated Albumin Correlates With Time-in-Range Better Than HbA1c or Fructosamine.

Cyrus V Desouza, Julio Rosenstock, Takuji Kohzuma, Vivian A Fonseca

2 registry-linked trialsOpen access · hybridAbstract read
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02489773 completednot on this map

Lucica ® Glycated Albumin-L Clinical Program - Pivotal Study

TypeobservationalSponsorAsahi Kasei Therapeutics CorporationRan2015 to 2016Enrolled150ConditionsDiabetes
NCT07777900 enrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Investigating Glycated Albumin Use for Short-Term and Additional/Alternate Monitoring of Blood Glucose Control

TypeobservationalSponsorWashington University School of MedicineRan2025 to 2027Enrolled100ConditionsDiabetes
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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  10. Glycated Albumin Correlates With Time-in-Range Better Than HbA1c or Fructosamine.The Journal of clinical endocrinology and metabolism · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Cyrus V DesouzaDepartment of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0001-6660-0568
Julio RosenstockVelocity Clinical Research at Medical City, Dallas, TX 75230, USA.ORCID 0000-0001-8324-3275
Takuji KohzumaResearch and Development Department, Asahi Kasei Pharma, Tokyo 100-0006, Japan.ORCID 0000-0002-6454-0490
Vivian A FonsecaSection of Endocrinology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA.ORCID 0000-0002-3381-7151
Asahi Kasei (Japan) · JPTulane University · USUniversity of Nebraska Medical Center · USVelocity Clinical Research (United States) · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI JUDD E SHELLITO · 2012 to 2026
$69.1M
NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

contextIntermediate-term glycemic control metrics may represent a viable alternative to continuous glucose monitoring (CGM) in patients without access to CGM.

objectiveThis work aimed to compare the relationship between CGM parameters and glycated albumin (GA), glycated hemoglobin A1c (HbA1c), and fructosamine for 24 weeks.

methodsWe conducted exploratory comparative analyses of CGM subgroup data from a previously published 24-week prospective study of assay performance in 8 US clinics. Participants included 34 individuals with type 1 (n = 18) and type 2 diabetes (n = 16) undergoing changes to improve glycemic control (n = 22; group 1) or with stable diabetes therapy (n = 12; group 2). Main outcome measures included Pearson correlations between CGM and glycemic indices and receiver operating characteristic (ROC) analysis of glycemic index values predictive of time in range (TIR) greater than 70%.

resultsAt weeks 4 and 8, GA correlations with TIR were higher than HbA1c correlations in group 1. In group 2, GA correlations with TIR were statistically significant, whereas HbA1c correlations were not. In both groups over the first 12 weeks, GA correlations with TIR were higher than fructosamine-TIR correlations. In the ROC analysis, GA predicted a TIR greater than 70% during weeks 2 to 24 (area under the curve >0.80); HbA1c was predictive during weeks 12 to 24. Cutoff values for TIR greater than 70% were 17.5% (sensitivity and specificity, 0.88) for GA and 7.3% (0.86) for HbA1c.

conclusionGA is the most accurate predictor of TIR over 8 weeks compared with other glycemic indices, which may assist in clinical evaluation of changes in treatment where CGM is not possible and it is too early to use HbA1c (NCT02489773).

Indexed as

Diabetes Mellitus, Type 2Blood GlucoseBlood Glucose Self-MonitoringFructosamineGlycated HemoglobinGlycated Serum AlbuminGlycation End Products, AdvancedHumansProspective StudiesSerum AlbuminBlood GlucoseFructosamineGlycated HemoglobinGlycated Serum AlbuminGlycation End Products, AdvancedSerum Albumincontinuous glucose monitoring (CGM)diabetesfructosamineglycated albuminHbA1c

Identifiers

PMID37259605
PMCPMC10583977
OpenAlexW4378952741

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.