Evidence map›Paper›PMID 37259596›Full record

ArticleThe EMBO journal2023

Nicotinamide N-methyltransferase sustains a core epigenetic program that promotes metastatic colonization in breast cancer.

Joana Pinto Couto, Milica Vulin, Charly Jehanno, Marie-May Coissieux, Baptiste Hamelin, Alexander Schmidt, Robert Ivanek, Atul Sethi, Konstantin Bräutigam, Anja L Frei and 8 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 29 citations in OpenAlex.

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  13. DNA Methylation-Regulated ZDHHC17 Promotes the Risk of Facial Skin Aging.Clinical, cosmetic and investigational dermatology · 2025
    Article
  14. Frontiers in pharmacology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 1 country.

Joana Pinto Couto *Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Milica Vulin *Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.ORCID 0000-0002-7686-5102
Charly Jehanno *Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.ORCID 0000-0002-2897-6027
Marie-May CoissieuxDepartment of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.ORCID 0000-0001-5017-5253
Baptiste HamelinDepartment of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Alexander SchmidtProteomics Core Facility, Biozentrum, University of Basel, Basel, Switzerland.ORCID 0000-0002-3149-2381
Robert IvanekDepartment of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.ORCID 0000-0002-8403-056X
Atul SethiDepartment of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Konstantin BräutigamComputational and Translational Pathology Group, Department of Pathology and Molecular Pathology, University Hospital Zurich, University of Zurich, Zürich, Switzerland.ORCID 0000-0002-3966-3579
Anja L FreiComputational and Translational Pathology Group, Department of Pathology and Molecular Pathology, University Hospital Zurich, University of Zurich, Zürich, Switzerland.
Carolina HagerDepartment of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Madhuri ManivannanDepartment of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Jorge Gómez-MiragayaDepartment of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.ORCID 0000-0003-1801-4681
Milan Ms ObradovićDepartment of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Zsuzsanna VargaComputational and Translational Pathology Group, Department of Pathology and Molecular Pathology, University Hospital Zurich, University of Zurich, Zürich, Switzerland.ORCID 0000-0002-2855-983X
Viktor H KoelzerComputational and Translational Pathology Group, Department of Pathology and Molecular Pathology, University Hospital Zurich, University of Zurich, Zürich, Switzerland.ORCID 0000-0001-9206-4885
Kirsten D MertzInstitute of Pathology, Cantonal Hospital Baselland, Liestal, Switzerland.ORCID 0000-0002-3074-6925
Mohamed Bentires-AljDepartment of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.ORCID 0000-0001-6344-1127
University of Basel · CHUniversity of Zurich · CHSIB Swiss Institute of Bioinformatics · CHKantonsspital Baselland · CHUniversity of Bern · CH

Funding

Swiss National Science Foundation
6 · The paper itself

Abstract

Metastatic colonization of distant organs accounts for over 90% of deaths related to solid cancers, yet the molecular determinants of metastasis remain poorly understood. Here, we unveil a mechanism of colonization in the aggressive basal-like subtype of breast cancer that is driven by the NAD

Indexed as

NeoplasmsNicotinamide N-MethyltransferaseAnimalsDNA MethylationEpigenesis, GeneticMiceNicotinamide N-Methyltransferasebreast cancercollagencolonizationmetastasisNNMT

Identifiers

PMID37259596
PMCPMC10308372
OpenAlexW4378952121

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.