Evidence map›Paper›PMID 37259457›Full record

ReviewPharmaceuticals (Basel, Switzerland)2023

PSMA-Targeted Nanotheranostics for Imaging and Radiotherapy of Prostate Cancer.

Niranjan Meher, Henry F VanBrocklin, David M Wilson, Robert R Flavell

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Comparison ofEuropean journal of nuclear medicine and molecular imaging · 2025
    Article
  11. Article
  12. Update on PSMA-based Prostate Cancer Imaging.Seminars in nuclear medicine · 2024
    Review
  13. Review
  14. PSMA-targeted combination brusatol and docetaxel nanotherapeutics for the treatment of prostate cancer.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024
    Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Niranjan MeherDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143, USA .
Henry F VanBrocklinDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143, USA .
David M WilsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143, USA .
Robert R FlavellDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143, USA .ORCID 0000-0002-8694-1199
University of California, San Francisco · US

Funding

Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alan Ashworth · 1999 to 2026
$209.7M
Molecular imaging of novel PARP inhibitor nanomedicine deliveryR01CA266666 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AGGARWAL, RAHUL, FLAVELL, ROBERT RICHARD · 2022 to 2025
$2.4M
Cancer Center Support Grant P30CA082103National Institute of Health (NIH) R01CA266666NCI NIH HHS P30 CA082103NCI NIH HHS R01 CA266666US Department of Defense W81XWH-20-1-0292
6 · The paper itself

Abstract

Targeted nanotheranostic systems offer significant benefits due to the integration of diagnostic and therapeutic functionality, promoting personalized medicine. In recent years, prostate-specific membrane antigen (PSMA) has emerged as an ideal theranostic target, fueling multiple new drug approvals and changing the standard of care in prostate cancer (PCa). PSMA-targeted nanosystems such as self-assembled nanoparticles (NPs), liposomal structures, water-soluble polymers, dendrimers, and other macromolecules are under development for PCa theranostics due to their multifunctional sensing and therapeutic capabilities. Herein, we discuss the significance and up-to-date development of "PSMA-targeted nanocarrier systems for radioligand imaging and therapy of PCa". The review also highlights critical parameters for designing nanostructured radiopharmaceuticals for PCa, including radionuclides and their chelators, PSMA-targeting ligands, and the EPR effect. Finally, prospects and potential for clinical translation is discussed.

Indexed as

enhanced permeability and retention (EPR) effectnanocarriersnanoparticlepositron emission tomography (PET)prostate cancer theranosticsprostate-specific membrane antigen (PSMA)radioligand theranosticsradiopharmaceutical therapysmall-molecule PSMA inhibitors

Identifiers

PMID37259457
PMCPMC9964110
OpenAlexW4321375071

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.