Evidence map›Paper›PMID 37259425›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Synthesis, Characterization, and Biological Evaluation of Meldrum's Acid Derivatives: Dual Activity and Molecular Docking Study.

Syed Nasir Abbas Bukhari, Mohamed Abdelwahab Abdelgawad, Naveed Ahmed, Muhammad Wahab Amjad, Muhammad Ajaz Hussain, Mervat A Elsherif, Hasan Ejaz, Nasser H Alotaibi, Ignjat Filipović, Nenad Janković

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Syed Nasir Abbas BukhariDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 72388, Al Jouf, Saudi Arabia.ORCID 0000-0001-8125-7972
Mohamed Abdelwahab AbdelgawadDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 72388, Al Jouf, Saudi Arabia.ORCID 0000-0001-9035-5638
Naveed AhmedDepartment of Pharmaceutics, College of Pharmacy, Jouf University, Sakaka 72388, Al Jouf, Saudi Arabia.ORCID 0000-0003-2312-3137
Muhammad Wahab AmjadCenter for Ultrasound Molecular Imaging and Therapeutics, Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15260, USA.ORCID 0000-0002-5832-8602
Muhammad Ajaz HussainCentre for Organic Chemistry, School of Chemistry, University of the Punjab, Lahore 54590, Pakistan.ORCID 0000-0003-4570-6616
Mervat A ElsherifChemistry Department, College of Science, Jouf University, Sakaka 72388, Al Jouf, Saudi Arabia.
Hasan EjazDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Al Jouf, Saudi Arabia.ORCID 0000-0002-6185-2042
Nasser H AlotaibiDepartment of Clinical Pharmacy, College of Pharmacy, Jouf University, Sakaka 72388, Al Jouf, Saudi Arabia.
Ignjat FilipovićUniversity of Kragujevac, Faculty of Science, Radoja Domanovića 12, 34000 Kragujevac, Serbia.ORCID 0000-0003-1307-6242
Nenad JankovićUniversity of Kragujevac, Department of Science, Institute for Information Technologies Kragujevac, Jovana Cvijića bb, 34000 Kragujevac, Serbia.ORCID 0000-0002-2295-9410

Funding

Deanship of Scientific Research at Jouf University DSR2022-RG-0148
6 · The paper itself

Abstract

In the presented study, eight novel Meldrum's acid derivatives containing various vanillic groups were synthesized. Vanillidene Meldrum's acid compounds were tested against different cancer cell lines and microbes. Out of nine, three showed very good biological activity against

Indexed as

anticancer activityantimicrobial activitygyrase BMeldrum’s acidtopoisomerase IIvanillin

Identifiers

PMID37259425
PMCPMC9968196

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.